ITE|CAS 448906-42-1|DC Chemicals

Cas No.:	448906-42-1
Chemical Name:	ITE
Synonyms:	Methyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate;ITE;2-(1H-Indol-3-ylcarbonyl)-4-thiazol ecarboxylic acid methyl ester;4-Thiazolecarboxylicacid, 2-(1H-indol-3-ylcarbonyl)-, methyl ester;methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate;HMS3268G16;2-(1H-INDOL-3-YLCARBONYL)-4-THIAZOLECARBOXYLIC ACID METHYL ESTER;AK116400;AHR agonist;The endogeneous AHR ligand;Aryl hydrocarbon receptor ligand;BCP17758;6191AB;SB17198;NCGC0
SMILES:	S1C([H])=C(C(=O)OC([H])([H])[H])N=C1C(C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)=O
Formula:	C₁₄H₁₀N₂O₃S
M.Wt:	286.3058
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

Cat. No.	Product name	Field of application
DC28934	VAF347	VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14+CD11b+ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects.
DC28914	AhR modulator-1	AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus.
DC11794	GNF-351	GNF-351 is a potent, pure aryl hydrocarbon receptor (AHR) antagonist (IC50=62 nM) devoid of partial agonist potential; antagonizes agonist and SAhRM-mediated suppression of SAA1, inhibit both DRE-dependent and -independent activity; decreases migration and invasion of HNSCC cells and prevents benzo[a]pyrene-mediated induction of the chemotherapy efflux protein ABCG2.
DC11530	Tapinarof (Benvitimod; GSK2894512)	Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice.
DC73809	ITE	A endogenous ligand, potent aryl hydrocarbon receptor (AhR) agonist in vitro.
DC73808	GDU-952	GDU-952 is a novel small molecule aryl hydrocarbon receptor (AhR) agonist, activates and induces nuclear translocation of AhR.
DC72107	DiMNF	DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent.
DC70554	KYN-101	KYN-101 (KYN101) is a potent, selective synthetic antagonist of aryl hydrocarbon receptor (AHR) with IC50 of 22 nM in human HepG2 DRE-luciferase reporter assay and 23 nM in murine Hepa1 Cyp-luc assay.KYN-101 reverses IDO/TDO-mediated tumor progression and improves the efficacy of PD-1 blockade in B16 IDO tumor-bearing mice, as well as CT26 colorectal cancer model expressing endogenous high levels of IDO.
DC49396	Flavipin	Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4+ T cells and CD11b+ macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA. Flavipin exhibits the DPPH free radical scavenging ability with IC50 value of 7.2 μM, and has potent α-glucosidase inhibition with IC50 value of 33.8 μM.
DC48592	Indolokine A5	Indolokine A5, a catabolite of L-cysteine, is a potent AhR agonist.