EN6|EN-6|CAS 1808714-73-9|DC Chemicals

Cas No.:	1808714-73-9
Chemical Name:	N-[4-fluoro-3-(prop-2-enamido)phenyl]-1-(2-fluorophenyl)-1H-pyrazole-4-carboxamide
Synonyms:	EN6
SMILES:	FC1C=CC(NC(C2C=NN(C3C=CC=CC=3F)C=2)=O)=CC=1NC(=O)C=C
Formula:	C₁₉N₄O₂F₂H₁₄
M.Wt:	368.3369
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner[1].

References:

[1]. Chung CY, et al. Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat Chem Biol. 2019 Aug;15(8):776-785.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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