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Diphemanil methylsulfate

  Cat. No.:  DCAPI1702   Featured
Chemical Structure
62-97-5
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Field of application
Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 62-97-5
Chemical Name: Diphemanil methylsulfate
Synonyms: DEMOTIL;4-benzhydrylidene-1,1-dimethylpiperidin-1-ium,methyl sulfate;Diphemanil mesylate;Diphemanil Methosulfate;Diphemanil Methylsulfate;DIPHEMANIL METHYLSULFATE, USP STANDARD;4-Benzhydryliden-1,1-dimethyl-piperidinium,Methylsulfat;4-benzhydrylidene-1,1-dimethyl-piperidinium,methyl sulfate;Diphemanil;Diphemanil metilsulfate;Diphenmanil (methylsulfate);Diphenmethanil;Nivelon;Nivelona;Prantal;Talpran;Variton;4-(Diphenylmethylene)-1,1-dimethylpiperidin-1-ium Methyl Sulfate;N,N-Dimethyl-4-piperidylidene-1,1-diphenylmethane methylsulfate;Diphenmanil methylsulfate;Diphemanilum;Diphemanili metilsulfas;Diphemanil methyl sulfate;Metilsulfato de difemanilo;Diphenmanil methyl sulfate;Metilsulfate de diphemanil;Vagophemanil;Vagophemanil methyl sulfate;Diphenmethanil methyl sulfate;Diphemanil methylsulphate;Ban-Guard (Veterinary);Diphen
SMILES: C[N+]1(C)CC/C(CC1)=C(C2=CC=CC=C2)\C3=CC=CC=C3.O=S(OC)([O-])=O
Formula: C21H27NO4S
M.Wt: 389.5084
Sotrage: 2 years -20°C powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Diphemanil methylsulfate is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC72037 CHF-6366 CHF-6366 is a potent M3 muscarinic antagonist and β2-adrenergic receptors agonist with pKi values of 10.4 and 11.4, respectively. CHF-6366 is also a weak calcium channel inhibitor (IC50~50 μM). CHF-6366 inhibits bronchoconstriction in guinea pigs.
DC9255 VU0357017 VU0357017 hydrochloride is a highly selective M1 agonists that appear to act at an allosteric site to activate the receptor (EC50 = 477 ± 172 nM; pEC50 = 6.37 ± 0.15).
DC9497 VU0152100 VU0152100 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM.
DC8153 Umeclidinium bromide Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD).
DCAPI1449 Tiotropium Bromide Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR M) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. This stops signaling between neurons and leads to muscle relaxation.
DC8813 TD-4208 TD-4208 is a potent and selective inhaled muscarinic antagonist with functional lung selectivity and long duration of action in preclinical models of bronchoconstriction.
DC7932 TBPB TBPB is an allosteric M1 mAChR agonist(EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats.
DC11208 TAK-071 TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM.
DC10012 Pirmenol hydrochloride Pirmenol hydrochloride inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM.
DC8435 LY2119620 LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.
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