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Home > Inhibitors & Agonists > GPCR > mAChR

CHF-6366

  Cat. No.:  DC72037   Featured
Chemical Structure
1615208-41-7
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Field of application
CHF-6366 is a potent M3 muscarinic antagonist and β2-adrenergic receptors agonist with pKi values of 10.4 and 11.4, respectively. CHF-6366 is also a weak calcium channel inhibitor (IC50~50 μM). CHF-6366 inhibits bronchoconstriction in guinea pigs.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1615208-41-7
Chemical Name: 1H-​Pyrazole-​3-​carboxylic acid, 5-​[[3-​[(S)​-​[[[(3R)​-​1-​azabicyclo[2.2.2]​oct-​3-​yloxy]​carbonyl]​amino]​phenylmethyl]​phenoxy]​methyl]​-​1-​methyl-​, 4-​[[(2R)​-​2-​(1,​2-​dihydro-​8-​hydroxy-​2-​oxo-​5-​quinolinyl)​-​2-​hydroxyethyl]​amino]​butyl ester
SMILES: [C@H](C1C=CC(O)=C2NC(=O)C=CC=12)(O)CNCCCCOC(C1=NN(C)C(COC2C=CC=C([C@H](C3C=CC=CC=3)NC(=O)O[C@H]3CN4CCC3CC4)C=2)=C1)=O
Formula: C42H48N6O8
M.Wt: 764.87
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_36347_DC72037_1615208-41-7
COA
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Cat. No. Product name Field of application
DC72037 CHF-6366 CHF-6366 is a potent M3 muscarinic antagonist and β2-adrenergic receptors agonist with pKi values of 10.4 and 11.4, respectively. CHF-6366 is also a weak calcium channel inhibitor (IC50~50 μM). CHF-6366 inhibits bronchoconstriction in guinea pigs.
DC9255 VU0357017 VU0357017 hydrochloride is a highly selective M1 agonists that appear to act at an allosteric site to activate the receptor (EC50 = 477 ± 172 nM; pEC50 = 6.37 ± 0.15).
DC9497 VU0152100 VU0152100 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM.
DC8153 Umeclidinium bromide Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD).
DCAPI1449 Tiotropium Bromide Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR M) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. This stops signaling between neurons and leads to muscle relaxation.
DC8813 TD-4208 TD-4208 is a potent and selective inhaled muscarinic antagonist with functional lung selectivity and long duration of action in preclinical models of bronchoconstriction.
DC7932 TBPB TBPB is an allosteric M1 mAChR agonist(EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats.
DC11208 TAK-071 TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM.
DC10012 Pirmenol hydrochloride Pirmenol hydrochloride inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM.
DC8435 LY2119620 LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.
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