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EST64454 hydrochloride

  Cat. No.:  DC42317   Featured
Chemical Structure
1950569-11-5
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Field of application
EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a Ki of 22 nM. EST64454 hydrochloride has the potential for the research of the pain.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1950569-11-5
Chemical Name: EST64454 hydrochloride
Synonyms: EST64454 hydrochloride;EST64454;EST64454 HCl;EST64454 (hydrochloride);1-[4-[2-[[1-(3,4-difluorophenyl)pyrazol-3-yl]methoxy]ethyl]piperazin-1-yl]ethanone;hydrochloride;BDBM50555105
SMILES: Cl.FC1=C(C=CC(=C1)N1C=CC(COCCN2CCN(C(C)=O)CC2)=N1)F
Formula: C18H23ClF2N4O2
M.Wt: 400.850630044937
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS
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MSDS_25924_DC42317_1950569-11-5
COA
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Cat. No. Product name Field of application
DC73504 JR1-157 JR1-157 is a potent selective sigma 2 receptor (σ2R) ligand with Ki value of 47 nM, >10-fold selectivity over σ1R.
DC48913 CM398 CM398 is a highly selective, orally active sigma-2 receptor ligand (Ki=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 shows notable affinity for dopamine (Ki=32.90 nM) and serotonin transporters (Ki=244.2 nM). CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice.
DC46854 BMY-14802 hydrochloride BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects.
DC46527 σ1 Receptor antagonist-1 σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28). σ1 Receptor antagonist-1 inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells.
DC42317 EST64454 hydrochloride EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a Ki of 22 nM. EST64454 hydrochloride has the potential for the research of the pain.
DC11545 IPAG IPAG is a prototypic selective inhibitor of sigma1 receptor that engages the unfolded protein response and induces autophagy in cancer cells.
DC11758 PB 28 dihydrochloride A potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively.
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