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σ1 Receptor antagonist-1

  Cat. No.:  DC46527   Featured
Chemical Structure
1204401-49-9
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More than 5000 active chemicals with high quality for research!
Field of application
σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28). σ1 Receptor antagonist-1 inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1204401-49-9
Chemical Name: σ1 Receptor antagonist-1
Synonyms: 4H-1-Benzothiopyran-4-one, 2,3-dihydro-2-[1-(phenylmethyl)-4-piperidinyl]-;2-(1-Benzyl-4-piperidinyl)-2,3-dihydro-4H-thiochromen-4-one;2-(1-Benzylpiperidin-4-yl)-2,3-dihydro-4H-thiochromen-4-one;2,3-dihydro-2-[1-(phenylmethyl)-4-piperidinyl]-4H-1-Benzothiopyran-4-one;σ1 Receptor antagonist-1;1204401-49-9;1204401-49-9;EX-A7549;EX-A7549;AKOS027420690;AKOS027420690;DB-364342;DB-364342;??1 Receptor antagonist-1;??1 Receptor antagonist-1;AS-84681;AS-84681;2-(1-benzylpiperidin-4-yl)-2,3-dihydro-1-benzothiopyran-4-one;2-(1-benzylpiperidin-4-yl)-2,3-dihydro-1-benzothiopyran-4-one;2-(1-benzylpiperidin-4-yl)-2,3-dihydrothiochromen-4-one;2-(1-benzylpiperidin-4-yl)-2,3-dihydrothiochromen-4-one;CHEMBL578825;CHEMBL578825;HY-10815;HY-10815;F76875;F76875;CS-0002837;CS-0002837;WQ 1;WQ 1;BDBM50415166;BDBM50415166;2-(1-Benzylpiperidin-4-yl)thiochroman-4-one;2-(1-Benzylpiperidin-4-yl)thiochroman-4-one
SMILES: C1=CC=C(C=C1)CN2CCC(CC2)C3CC(=O)C4=CC=CC=C4S3
Formula: C21H23NOs
M.Wt: 337.47842
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC73507 WLB-89462 WLB-89462 (WLB89462) is a potent, highly selective sigma-2 receptor (σ2R) ligand with Ki of 13 nM, >100-fold selective over σ1R (Ki=1777 nM).
DC73504 JR1-157 JR1-157 is a potent selective sigma 2 receptor (σ2R) ligand with Ki value of 47 nM, >10-fold selectivity over σ1R.
DC48913 CM398 CM398 is a highly selective, orally active sigma-2 receptor ligand (Ki=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 shows notable affinity for dopamine (Ki=32.90 nM) and serotonin transporters (Ki=244.2 nM). CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice.
DC46854 BMY-14802 hydrochloride BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects.
DC46527 σ1 Receptor antagonist-1 σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28). σ1 Receptor antagonist-1 inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells.
DC42317 EST64454 hydrochloride EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a Ki of 22 nM. EST64454 hydrochloride has the potential for the research of the pain.
DC11545 IPAG IPAG is a prototypic selective inhibitor of sigma1 receptor that engages the unfolded protein response and induces autophagy in cancer cells.
DC11758 PB 28 dihydrochloride A potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively.
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