Fer-1|Ferrostatin-1|CAS 347174-05-4|DC Chemicals

Cas No.:	347174-05-4
Chemical Name:	Ethyl 3-amino-4-(cyclohexylamino)benzoate
Synonyms:	Ethyl 3-amino-4-(cyclohexylamino)benzoate;Ferrostatin-1 (Fer-1);ethyl 3-amino-4-cyclohexylaminobenzoate;Ferrostatin 1;Ferrostatin-1;3-amino-4-cyan-1-phenyl-pyrrol-2-carbonsaeureethylester;3-Amino-4-cyclohexylamino benzoic acid ethyl ester;3-amino-4-cyclohexylamino-benzoic acid ethyl ester;AC1LDIR8;AG-G-09537;CTK1E8332;ethyl 3-amino-4-cyano-1-phenyl-1H-pyrrole-2-carboxylate;HMS2445A21;Fer-1;Benzoic acid, 3-amino-4-(cyclohexylamino)-, ethyl ester;ferrostatin-1-fer-1;UJHBVMHOBZBWMX-UHFFFAOYSA-N;HMS3653M21;BCP17366;s7243;SB19587;SEL10496268;SEL10496253;ST45002378;SW2
SMILES:	O(C([H])([H])C([H])([H])[H])C(C1C([H])=C([H])C(=C(C=1[H])N([H])[H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=O
Formula:	C₁₅H₂₂N₂O₂
M.Wt:	262.3474
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Ferrostatin-1 is a potent inhibitor of ferroptosis with an EC50 of 60 nM.

In Vitro:

Ferrostatin-1 is the most potent inhibitor of erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1 does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS[1]. Cells pretreated with 0.4 μM Ferrostatin-1 displays significantly reduce intracellular reactive oxygen species (ROS) and nitrogen species (RNS) below basal levels. Additionally, increased intracellular ROS levels are also significantly lowered below basal levels by a 0.4 µM Ferrostatin-1 pretreatment. Ferrostatin-1 treatment for 24 h does not change the expression level of i-NOS in SHSY-5Y cell when compare with vehicle (0.02 % DMSO) treated cells[2].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC9746	RSL3	RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS.
DC7920	Liproxstatin-1	Liproxstatin-1 is able to suppress ferroptosis in cells, in Gpx4(-/-) mice, and in a pre-clinical model of ischaemia/reperfusion-induced hepatic damage.
DC10522	FIN56	FIN56 is a specific inducer of ferroptosis.
DC10742	Ferrostatin-1 (Fer-1)	Ferrostatin-1 is a selective inhibitor of erastin induced ferroptosis with EC50 value of 60 nM.
DC10839	CIL56(CA3)	CIL56 is a small molecule that induces cellular ferroptosis through production of iron-dependent reactive oxygen species (ROS).

Ferrostatin-1 (Fer-1)