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GRP-60367

  Cat. No.:  DC31005   Featured
Chemical Structure
1309241-34-6
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More than 5000 active chemicals with high quality for research!
Field of application
GRP-60367 is a first-in-class direct-acting RABV inhibitor with EC50 from 2 to 52 nM (different host cell lines) that blocks RABV G protein-mediated viral entry.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1309241-34-6
Synonyms: GRP-60367;GRP-60367;GRP-60367
SMILES: O=C(C1C=CN=CC=1)N1CCC(NCCOC2C(C)=CC=C(C)C=2)CC1
Formula: C21H27N3O2
M.Wt: 353.46
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Venice Du Pont, et al. Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor. J Virol. 2020 Jun 16;94(13):e00321-20.
Description: GRP-60367 is a first-in-class small-molecule rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains[1].
Target: RABV[1]
In Vitro: GRP-60367 inhibits entry of a subset of RABV strains. GRP-60367 shows specific and potent anti-RABV activity of the scaffold, returning in dose-response assays EC50s ranging from 2 to 52 nM on different host cell lines[1].
References: [1]. Venice Du Pont, et al. Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor. J Virol. 2020 Jun 16;94(13):e00321-20.
MSDS
COA
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2018-0101
2018-0101
2018-0101
2018-0101
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