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| Cas No.: | 1903763-83-6 |
| Chemical Name: | 1'-((5-(Aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-6'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one hydrochloride |
| Synonyms: | RV521 hydrochloride; RV-521; RV 521; RV521; Sisunatovir HCl; Sisunatovir hydrochloride; |
| SMILES: | O=C(C12CC1)N(CC3=NC4=CC(CN)=CC=C4N3CCCC(F)(F)F)C5=C2C=CC(F)=C5.[H]Cl |
| Formula: | C23H23ClF4N4O |
| M.Wt: | 482.91 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Sisunatovir, also known as RV521, is a highly potent fusion inhibitor with efficacy against a panel of clinical isolates of RSV-A and RSV-B viruses. RV521 exhibited a mean IC50 of 1.2 nM against a panel of RSV A and B laboratory strains and clinical isolates with antiviral efficacy in the Balb/C mouse model of RSV infection. Oral bioavailability in preclinical species ranged from 42 to >100% with evidence of highly efficient penetration into lung tissue. In healthy adult human volunteers experimentally infected with RSV, a potent antiviral effect was observed with a significant reduction in viral load and symptoms compared to placebo. |
MSDS
| TITLE | DOWNLOAD |
| MSDS_27679_DC51001_1903763-83-6 |
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COA
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