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ICA 069673

  Cat. No.:  DC10078   Featured
Chemical Structure
582323-16-8
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More than 5000 active chemicals with high quality for research!
Field of application
ICA 069673 is a potassium channel opener with selective action for KCNQ2 and KCNQ3 (EC50=0.69 μM). No meeasurable activity was displayed over a variety of cardiac ion channels.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 582323-16-8
Chemical Name: N-(2-chloro-5-pyrimidinyl)-3,4-difluorobenzamide
Synonyms: N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide;ICA 069673;N-(2-Chloro-5-pyrimidinyl)-3,4-difluoro-benzamide;ICA-069673
SMILES: O=C(NC1=CN=C(Cl)N=C1)C2=CC=C(F)C(F)=C2
Formula: C11H6N3OF2Cl
M.Wt: 269.63464
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: ICA-069673 is a KCNQ2/Q3 potassium channel activator with an IC50 of 0.69 μM.
In Vitro: ICA-069673 is found to be 20-fold selective for KCNQ2/Q3 over KCNQ3/Q5 and has no measurable activity against a panel of cardiac ion channels (IC50 values > 30 μM for hERG, Nav1.5, L type channels, and KCNQ1) as well as no activity on GABA(A) gated channels at 10 μM[1]. ICA-069673 exhibits much stronger effects on KCNQ2 channels, including a large hyperpolarizing shift of the voltage-dependence of activation, an 2-fold enhancement of peak current and pronounced subtype specificity for KCNQ2 over KCNQ3. Based on ICA73 sensitivity of chimeric constructs of the transmembrane segments of KCNQ2 and KCNQ3, this drug appears to interact with the KCNQ2 voltage sensor (S1-S4)[2].
References: [1]. Wickenden AD, et al. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73(3):977-86. Epub 2007 Dec 18. [2]. Wang AW, et al. Sequence determinants of subtype-specific actions of KCNQ channel openers. J Physiol. 2017 Feb 1;595(3):663-676.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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