ml335

  Cat. No.:  DC10743   Featured
Chemical Structure
825658-06-8
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More than 5000 active chemicals with high quality for research!
Field of application
ML335 is a selective activator of both TREK-1 and TREK-2.
Cas No.: 825658-06-8
Chemical Name: N-[(2,4-Dichlorophenyl)methyl]-4-(methanesulfonamido)benzamide
Synonyms: ML335; ML-335; ML 335; TREK-1/2 Activator
SMILES: O=C(NCC1=CC=C(Cl)C=C1Cl)C2=CC=C(NS(=O)(C)=O)C=C2
Formula: C15H14Cl2N2O3S
M.Wt: 373.24
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: ML335 is a selective activator of both TREK-1 and TREK-2.
In Vitro: Xenopus oocyte two-electrode voltage-clamp measurements show that ML335 and ML402 activate K2P2.1 and K2P10.1 but not K2P4.1 (14.3±2.7 μM, K2P2.1-ML335; 13.7±7.0 μM, K2P2.1-ML402; 5.2±0.5 μM, K2P10.1-ML335; and 5.9±1.6 μM, K2P10.1-ML402). Swapping the Lys271 equivalent between K2P2.1 and K2P4.1 results in a clear phenotype reversal for ML335 and M402 activation. ML335 and ML402 activate K2P2.1 in HEK293 cells similar to their effects in Xenopus oocytes (5.2±0.8 μM and 5.9±1.6 μM for ML335 and ML402, respectively (n≥3))[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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