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Home > Inhibitors & Agonists > Membrane Transporter/Ion Channel > Potassium Channel

NS 11021

  Cat. No.:  DC8789   Featured
Chemical Structure
956014-19-0
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More than 5000 active chemicals with high quality for research!
Field of application
NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 956014-19-0
Chemical Name: NS 11021
Synonyms: NS 11021;N'-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-N-[4-BROMO-2-(2H-TETRAZOL-5-YL-PHENYL]THIOUREA;N′-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-thiourea;ns11021;1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea;Thiourea, N'-[3,5-bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-;1-(3,5-Bis-trifluoromethyl-phenyl)-3-[4-bromo-2-(1H-tetrazol-5-yl)-phenyl]-thiourea;1-[3,5-bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]thiourea;C16H9BrF6N6S;SYN5051;AOB1480;BCP16316;N′-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]thiourea (ACI);1-[3,5-Bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(1H-tetrazol-5-yl)phenyl]thiourea
SMILES: FC(C1C=C(C(F)(F)F)C=C(NC(NC2C(C3NN=NN=3)=CC(Br)=CC=2)=S)C=1)(F)F
Formula: C16H9BrF6N6S
M.Wt: 511.242280721664
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: NS 11021 is a potent and specific Ca2-activated big-conductance K＋ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials[1].
Target: Ca2＋-activated big-conductance K＋ Channels[1]
References: [1]. Bentzen BH，et al. The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol Pharmacol. 2007 Oct;72(4):1033-44.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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