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Illudin M

  Cat. No.:  DC40300   Featured
Chemical Structure
1146-04-9
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More than 5000 active chemicals with high quality for research!
Field of application
Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus olearius mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1146-04-9
Chemical Name: Illudin M
Synonyms: Spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one,2',3'-dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethyl-, (3'S,6'R)-;illudin M;Spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one, 2',3'-dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethyl-,(3'S-trans)-;(3'S,6'R)-3',6'-dihydroxy-2',2',4',6'-tetramethyl-2',3'-dihydrospiro[cyclopropane-1,5'-inden]-7'(6'H)-one;BRN 2286081;CCRIS 3539;DR-15977;Illudine M;NSC 400978;NSC 626370;Spiro(cyclopropane-1,5'-(5H)inden)-7'(6'H)-one, 2',3'-dihydro-3'-beta,6'-alpha-dihydroxy-2',24',6'-tetramethyl-;Illudin M
SMILES: CC1(C=C2C(=C(C3([C@](C2=O)(C)O)CC3)C)[C@H]1O)C
Formula: C15H20O3
M.Wt: 248.3175
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
Description: Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus olearius mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities[1][2].
In Vitro: Illudin M (0.01-10 μM; 24-120 hours) shows cytotoxicity and induction of apoptosis in vitro[1]. Apoptosis Analysis[1] Cell Line: Panc-1 pancreatic carcinoma, HT-29 colon adenocarcinoma, non-malignant human foreskin fibroblasts (HFs) Concentration: 0.01 μM, 1 μM, 10 μM Incubation Time: 24 hours, 48 hours,72 hours, 96 hours, 120 hours Result: Showed a comparable induction of apoptosis in the tumour cells (86% in Panc-1; 48% in HT-29), but an even greater one in the HF (89%).
References: [1]. Rainer Schobert, et al. Conjugates of the fungal cytotoxin illudin M with improved tumour specificity. Bioorg Med Chem. 2008 Sep 15;16(18):8592-7. [2]. Dr. Philipp Le, et al. A Chemical Proteomic Analysis of Illudin‐Interacting Proteins. Chemistry. 2019 Sep 25; 25(54): 12644–12651.
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