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Ivachtin

  Cat. No.:  DC29101   Featured
Chemical Structure
745046-84-8
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Field of application
Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 745046-84-8
Chemical Name: IVACHTIN
SMILES: CC(=O)OCCN1C(=O)C2C(=C(C)N=C3C=2C=C(C=C3)S(=O)(=O)N4CCOCC4)C1=O
Formula: C20H21N3O7S
M.Wt: 447.46164
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases[1].
Target: Caspase-3:23 nM (IC50)
In Vitro: Ivachtin (Caspase-3 Inhibitor VII; compound 7a; 10, 100 μM) has protective effect in a model of staurosporininduced apoptosis in human Jurkat T cells[1].
References: [1]. Kravchenko DV, et al. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. J Med Chem. 2005 Jun 2;48(11):3680-3.
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Cat. No. Product name Field of application
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