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Jatrorrhizine

  Cat. No.:  DC23040   Featured
Chemical Structure
3621-38-3
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More than 5000 active chemicals with high quality for research!
Field of application
Phytochemical alkaloid found in medicinal plants. Anti-inflammatory. Exhibits neuroprotective, antioxidative and gastrointestinal modulatory activities.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 3621-38-3
SMILES: COC1=CC=C2C=C3[N+](CCC4=C3C=C(OC)C(O)=C4)=CC2=C1OC
Formula: C20H20NO4
M.Wt: 338.38
Purity: >98%, Standard References Grade
Sotrage: 4°C for 1 year, -20°C for more than 2 years
Description: Jatrorrhizine is a potent and orally active uptake-2 transporter inhibitor, it can be isolated from various Chinese medicinal plants[1]. Jatrorrhizine exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of MAPK pathway in HT22 hippocampal neurons[2].
Target: Uptake-2 transporter[1]
In Vitro: Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters[1]. Jatrorrhizine significantly inhibits the plasma membrane monoamine transporter (PMAT) -mediated MPP+ uptake in a concentration-dependent manner with an IC50 value of 1.05 μM[1]. Jatrorrhizine demonstrates a more powerful inhibition on serotonin (5-HT) and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT[1]. Jatrorrhizine attenuates the H2O2-induced Bcl-2/Bax ratio reduction and caspase-3 activation in these neurons[2].
References: [1]. Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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