LMPTP inhibitor 23

  Cat. No.:  DC10836   Featured
Chemical Structure
1908414-82-3
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More than 5000 active chemicals with high quality for research!
Field of application
LMPTP inhibitor 1 is a potent molecule for diabetes which can increase liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes by inhibiting the IR phosphatase LMPTP.
Cas No.: 1908414-82-3
Chemical Name: N,N-diethyl-4-[4-[[3-(1-piperidinyl)propyl]amino]-2-quinolinyl]-benzamide
SMILES: C(N(CC)C(=O)C1C=CC(C2C=C(NCCCN3CCCCC3)C3C(=CC=CC=3)N=2)=CC=1)C
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: LMPTP inhibitor 23 is a potent, selective, orally bioavailable low-molecular-weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 0.8 uM; displays exquisite selectivity for LMPTP versus other PTPs including PTP1B, shows greater potency on LMPTP-A versus LMPTP-B; inhibits uncompetitively LMPTP with Ki of 846 nM, substantially increases HepG2 IR phosphorylation after insulin stimulation and reversess diabetes in mice without causing overt toxicity or weight loss.
References: References 1. Stanford SM, et al. Nat Chem Biol. 2017 Jun;13(6):624-632. View Related Products by Target Protein Phosphatase/PTP
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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