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TPI-1

  Cat. No.:  DC10088   Featured
Chemical Structure
79756-69-7
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More than 5000 active chemicals with high quality for research!
Field of application
TPI-1 is a potent and selective SHP-1 inhibitor effective at low nanomolar levels.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 79756-69-7
Chemical Name: TPI1,TPI 1
Synonyms: TPI1,TPI 1
SMILES: ClC1=CC(C2=CC(C=CC2=O)=O)=C(Cl)C=C1
Formula: C12H6Cl2O2
M.Wt: 253.08
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: TPI-1 is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM.
In Vivo: TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ+ cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent[1].
In Vitro: SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ+ cells and induces IFNγ+ cells in human peripheral blood[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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