| DC71995 |
PSB-06126
|
PSB-06126 is a selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with the Ki values of 0.33 μM for rat NTPDase 1, 19.1 μM for NTPDase 2 and 2.22 μM for NTPDase 3, respectively. |
| DC70739 |
RMC-4630
|
RMC-4630 is a potent and selective inhibitor of SHP2, a central node in the RAS signaling pathway. |
| DC70502 |
IACS-15414
|
IACS-15414 (IACS 15414) is a potent, selective, orally bioavailable SHP2 inhibitor with IC50 of 122 nM;
IACS-15414 potently suppressed the mitogen-activated protein kinase (MAPK) pathway signaling and tumor growth in RTK-activated and KRASmut xenograft models in vivo.
IACS-15414 potently suppressed the mitogen-activated protein kinase (MAPK) pathway signaling and tumor growth.
IACS-15414 had excellent PK properties across species but a narrow hERG window. |
| DC11021 |
KY-226
|
KY-226 (KY226) is a potent, allosteric, orally active inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 uM (human PTP1B), does not exhibit PPARγ agonist activity. |
| DC10088 |
TPI-1
|
TPI-1 is a potent and selective SHP-1 inhibitor effective at low nanomolar levels. |
| DC9737 |
SHP099 hydrochloride
|
SHP099 is a selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. |
| DC10004 |
SHP099 free base
|
SHP099 is a selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. |
| DC12051 |
RMC-4550
|
RMC-4550 (RMC4550) is a potent, selective, allosteric inhibitor of SHP2 with IC50 of 0.58 nM (full-length SHP2 enzyme), suppresses pERK signaling in Calu-1 cells with IC50 of 7 nM. |
| DC10878 |
Raphin1
|
Raphin1 is an orally available selective phosphatase inhibitor improves proteostasis and
diminishes deficits in a mouse model of Huntington’s disease. |
| DC9999 |
NQ301
|
NQ301 is a selective CD45 inhibitor (IC50 = 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases. |
