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Home > Inhibitors & Agonists > Metabolic Enzyme/Protease > Protein Phosphatase/PTP

IACS-15414

  Cat. No.:  DC70502   Featured
Chemical Structure
2411321-29-2
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More than 5000 active chemicals with high quality for research!
Field of application
IACS-15414 (IACS 15414) is a potent, selective, orally bioavailable SHP2 inhibitor with IC50 of 122 nM; IACS-15414 potently suppressed the mitogen-activated protein kinase (MAPK) pathway signaling and tumor growth in RTK-activated and KRASmut xenograft models in vivo. IACS-15414 potently suppressed the mitogen-activated protein kinase (MAPK) pathway signaling and tumor growth. IACS-15414 had excellent PK properties across species but a narrow hERG window.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2411321-29-2
Chemical Name: IACS-15414
Synonyms: IACS-15414
SMILES: C1(C)=NC(N2CCC3(CO[C@@H](C)[C@H]3N)CC2)=CC(=O)N1C1=CC=CC(Cl)=C1Cl
Formula: C20H24Cl2N4O2
M.Wt: 423.336162567139
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC71995 PSB-06126 PSB-06126 is a selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with the Ki values of 0.33 μM for rat NTPDase 1, 19.1 μM for NTPDase 2 and 2.22 μM for NTPDase 3, respectively.
DC70739 RMC-4630 RMC-4630 is a potent and selective inhibitor of SHP2, a central node in the RAS signaling pathway.
DC70502 IACS-15414 IACS-15414 (IACS 15414) is a potent, selective, orally bioavailable SHP2 inhibitor with IC50 of 122 nM; IACS-15414 potently suppressed the mitogen-activated protein kinase (MAPK) pathway signaling and tumor growth in RTK-activated and KRASmut xenograft models in vivo. IACS-15414 potently suppressed the mitogen-activated protein kinase (MAPK) pathway signaling and tumor growth. IACS-15414 had excellent PK properties across species but a narrow hERG window.
DC11021 KY-226 KY-226 (KY226) is a potent, allosteric, orally active inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 uM (human PTP1B), does not exhibit PPARγ agonist activity.
DC10088 TPI-1 TPI-1 is a potent and selective SHP-1 inhibitor effective at low nanomolar levels.
DC9737 SHP099 hydrochloride SHP099 is a selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM.
DC10004 SHP099 free base SHP099 is a selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM.
DC12051 RMC-4550 RMC-4550 (RMC4550) is a potent, selective, allosteric inhibitor of SHP2 with IC50 of 0.58 nM (full-length SHP2 enzyme), suppresses pERK signaling in Calu-1 cells with IC50 of 7 nM.
DC10878 Raphin1 Raphin1 is an orally available selective phosphatase inhibitor improves proteostasis and diminishes deficits in a mouse model of Huntington’s disease.
DC9999 NQ301 NQ301 is a selective CD45 inhibitor (IC50 = 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases.
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