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Home > Inhibitors & Agonists > Metabolic Enzyme/Protease > Protein Phosphatase/PTP

RMC-4550

  Cat. No.:  DC12051   Featured
Chemical Structure
2172651-73-7
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More than 5000 active chemicals with high quality for research!
Field of application
RMC-4550 (RMC4550) is a potent, selective, allosteric inhibitor of SHP2 with IC50 of 0.58 nM (full-length SHP2 enzyme), suppresses pERK signaling in Calu-1 cells with IC50 of 7 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2172651-73-7
Synonyms: RMC-4550,RMC 4550,RMC4550
SMILES: ClC1=C(Cl)C(C2=NC(CO)=C(N3CCC4(CO[C@@H](C)[C@H]4N)CC3)N=C2C)=CC=C1
Formula: C21H26Cl2N4O2
M.Wt: 437.365
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM.
Target: IC50:0.583 nM (SHP2)[1].
In Vitro: RMC-4550 is an allosteric inhibitor of SHP2 and stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. Consistent with an allosteric mode of inhibition, RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but lacks activity against the free catalytic domain of SHP2[1].
References: [1]. Nichols RJ, et al. RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers. Nat Cell Biol. 2018 Sep;20(9):1064-1073.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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