| Cas No.: | 1430213-30-1 |
| Synonyms: | ML 216; ML-216; CID-49852229; CID49852229; CID 49852229 |
| SMILES: | N(C1=CC=C(F)C(C(F)(F)F)=C1)C(NC1=NN=C(C2C=CN=CC=2)S1)=O |
| Formula: | C15H9F4N5Os |
| M.Wt: | 383.32 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | ML216(CID-49852229) is a potent inhibitor of the DNA unwinding activity of BLM helicase; showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively.ML216 shows cell-based activity, and can induce sister chromatid exchanges, enhance to the toxicity of aphidicolin and exert anti-proliferative activity in cells expressing BLM, but not in those lacking BLM. |
| Target: | IC50 value: 3.0/0.97 uM(Full length/636–1298 BLM) Target: BLM helicase inhibitor |
| References: | [1]. Nguyen GH, et al. A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. Chem Biol. 2013 Jan 24;20(1):55-62. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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