ML-277|ML277|activator of KCNQ1(K(v)7.1) channels

Cas No.:	1401242-74-7
Chemical Name:	ML277,ML 277, ML-277
Synonyms:	ML277,ML 277, ML-277
SMILES:	CC1=CC=C(C=C1)S(=O)(=O)N2CCCC[C@@H]2C(=O)NC3=NC(=CS3)C4=CC=C(C=C4)OC
Formula:	C₂₃H₂₅N₃O₄S₂
M.Wt:	471.592
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.ML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
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DC8807	Retigabine dihydrochloride	Retigabine 2Hcl (Ezogabine; D23129) is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity.
DC8269	NS6180	NS6180 is a novel inhibitor of the intermediate-conductance Ca2+-activated K+ channel (KCa3.1)
DC7833	NS309	NS309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.
DC6910	NS-1643	NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM).
DC9734	NS-1619	NS-1619 is a selective MaxiKα (large conductance calcium activated potassium channel) activator.
DC8789	NS 11021	NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1).
DC10557	ML402	ML402 is a selective TREK-1 activator.
DC7797	ML365	ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3) with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiology assay).
DC10743	ml335	ML335 is a selective activator of both TREK-1 and TREK-2.