Necrostatin 2 racemate

Cas No.:	852391-15-2
Chemical Name:	5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione
Synonyms:	Necrostatin-2; (±)-Necrostatin-2; 7-Cl-O-Nec-1; Nec-1s;
SMILES:	CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl
Formula:	C13H12ClN3O2
M.Wt:	277.708
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.Necrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers.Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins).
Target:	IC50 Value: 50 nM (EC50) [1] Target: TNF-alpha
References:	[1]. Teng X, Keys H, Jeevanandam A, Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6836-40. [2]. Jagtap PG, Degterev A, Choi S, Structure-activity relationship study of tricyclic necroptosis inhibitors. J Med Chem. 2007 Apr 19;50(8):1886-95. [3]. Teng X, Degterev A, Jagtap P, Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5039-44.