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Rezafungin

  Cat. No.:  DC28220   Featured
Chemical Structure
1396640-59-7
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More than 5000 active chemicals with high quality for research!
Field of application
Rezafungin (Biafungin) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp..
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1396640-59-7
Chemical Name: 2-[[(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S,26S)-6-[(1S,2S)-1,2-Dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,25-trihydroxy-3,15-bis[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-18-[[4-[4-(4-pentoxyphenyl)phenyl]benzoyl]amino]-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-21-yl]oxy]ethyl-trimethylazanium
Synonyms: Rezafungin (USAN/INN);D11197;2-[[(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S,26S)-6-[(1S,2S)-1,2-Dihydroxy-2-(4-hydroxyphenyl)ethyl]-11
SMILES: O[C@@H]1[C@H]2C(N[C@H]([C@@H](C[C@@H](C(N[C@@H]([C@@H](C)O)C(N3C[C@@H](C[C@H]3C(N[C@@H]([C@@H]([C@H](C3C=CC(=CC=3)O)O)O)C(N[C@@H]([C@@H](C)O)C(N2C[C@@H]1C)=O)=O)=O)O)=O)=O)NC(C1C=CC(C2C=CC(C3C=CC(=CC=3)OCCCCC)=CC=2)=CC=1)=O)O)OCC[N+](C)(C)C)=O
Formula: C63H85N8O17
M.Wt: 1226.3924176693
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Rezafungin (Biafungin) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp.[1][2].
In Vivo: Rezafungin (Biafungin) shows potent in vivo efficacy as prophylaxis against Pneumocystis in an in vivo mouse infection model[1]. Animal Model: C3H/HeN mice[1] Dosage: 1 mg/kg Administration: Intraperitoneal injection; once daily for 6 days Result: Significantly reduced nuclei and asci burdens.
References: [1]. Melanie Cushion, et al. Rezafungin Prophylactic Efficacy in a Mouse Model of Pneumocystis Pneumonia. VOLUME 25, ISSUE 3, SUPPLEMENT, S366, MARCH 01, 2019. [2]. Sofjan AK, et al. Rezafungin (CD101), a next-generation echinocandin: A systematic literature review and assessment of possible place in therapy. J Glob Antimicrob Resist. 2018 Sep;14:58-64.
MSDS
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MSDS_12275_DC28220_1396640-59-7
COA
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Cat. No. Product name Field of application
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DC28220 Rezafungin Rezafungin (Biafungin) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp..
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