| Cas No.: | 127785-64-2 |
| Chemical Name: | Aureobasidin A (9CI) |
| Synonyms: | Aureobasidin A (9CI);10,12-tetradecanhexaenylidene]-3,5-dioxo,(2S,4E);2-[(2S)-4-[(2E,4E,6E,8E,10Z,12E)-11,13-dichlorotetradeca-2,4,6,8,10,12-hexaenoyl]-1-[(3S,4R,5R)-3-[(2S,3S,4R,5R)-5-[(2S,3S,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]oxy-3,4-dihydroxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]-5-hydroxy-3-oxo-2H-pyrrol-2-yl]acetamide;AC1O52N9;aurantoside B;aureobasidin A;LY-295337;Basifungin;Aureobasidin A (AbA);Cyclo[L-Phe-N-methyl-L-Phe-L-Pro-L-aIle-N-methyl-L-Val-L-Leu-N-methyl-β-hydroxy-L-Val-[(3R)-D-Hmp-]-N-methyl-L-Val-] |
| SMILES: | CC[C@H]([C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC2C=CC=CC=2)N(C)C(=O)[C@H](CC2C=CC=CC=2)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]([C@@H](CC)C)OC(=O)[C@H](C(O)(C)C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)N(C)C1=O)C |
| Formula: | C60H92N8O11 |
| M.Wt: | 1101.41949653625 |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Aureobasidin A (Basifungin), a cyclic depsipetide, is an antifungal antibiotic. Aureobasidin A (Basifungin) A is an inhibitor of the inositolphosphorylceramide synthase AUR1[1][2]. |
| In Vitro: | Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides[2]. |
| References: | [1]. K Ikai, et al. Structure of aureobasidin A. J Antibiot (Tokyo). 1991 Sep;44(9):925-33. [2]. Vanessa Cerantola, et al. Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides. Mol Microbiol. 2009 Mar;71(6):1523-37. [3]. K Kino, et al. Aureobasidin A, an antifungal cyclic depsipeptide antibiotic, is a substrate for both human MDR1 and MDR2/P-glycoproteins. FEBS Lett. 1996 Dec 9;399(1-2):29-32. |
MSDS
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| MSDS_29973_DC46180_127785-64-2 |
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COA
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