SEN177|QPCT inhibitor

Cas No.:	2117405-13-5
Chemical Name:	6'-Fluoro-4-(4-methyl-4H-[1,2,4]triazol-3-yl)-3,4,5,6-tetrahydro-2H-[1,2';3',3'']terpyridine
Synonyms:	SEN177，SEN 177
SMILES:	CN1C(C2CCN(C3=NC(F)=CC=C3C4=CC=CN=C4)CC2)=NN=C1
Formula:	C₁₈H₁₉FN₆
M.Wt:	338.39
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

SEN177 is an inhibitor of glutaminyl cyclase (QPCT), thereby rescuing the Huntington's disease (HD)-related phenotypes in cell.

In Vitro:

SEN177 is a Glutaminyl cyclase (QPCT) inhibitor. Glutaminyl cyclase modifies N-terminal glutamine or glutamate residues to N-terminal 5-oxoproline or pyroglutamate (named QPCT). QPCT inhibits mutant huntingtin from forming aggregates, but also reduces aggregation of other aggregate-prone proteins containing polyQ or polyA repeats. SEN177 caused dose-dependent decreases in HTT aggregation by a mechanism that requires QPCT inhibition. SEN177 had in vitro activity against polyglutamine toxicity and was able to reduce aggregates in mammalian cells, primary neurons and in a Drosophila model.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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SEN-177