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SR17018

  Cat. No.:  DC10804   Featured
Chemical Structure
2134602-45-0
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Field of application
SR17018 is a Mu opioid agonists which was made to promote signaling through G proteins or barrestin2.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2134602-45-0
Chemical Name: 5,6-dichloro-1-(1-(4-chlorobenzyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one methanesulfonate
Synonyms: SR1 7018,SR-17018,SR17018
SMILES: C1=CC(CN2CCC(N3C(=O)NC4C=C(Cl)C(Cl)=CC3=4)CC2)=CC=C1Cl
Formula: C19H18Cl3N3O
M.Wt: 410.72
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM.
Target: EC50: 97 nM (MOR)[1]
In Vitro: SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM. SR17018 shows no obvious effect on inducing βarrestin2 recruitment to the MOR at below 10 μM. SR17018 promotes signaling through G proteins or βarrestin2[1].
References: [1]. Schmid CL, et al. Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics. Cell. 2017 Nov 16;171(5):1165-1175.e13.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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