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Thalidomide-NH-CH2-COOH

  Cat. No.:  DC42463  
Chemical Structure
927670-97-1
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Field of application
Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 927670-97-1
Chemical Name: Thalidomide-NH-CH2-COOH
Synonyms: Glycine,N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;N-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]glycine (ACI);(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine;2-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-ylamino)acetic acid;2-[[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino]acetic acid;Thalidomide-NH-CH2-COOH
SMILES: O=C(CNC1C2=C(C(N(C3CCC(=O)NC3=O)C2=O)=O)C=CC=1)O
Formula: C15H13N3O6
M.Wt: 331.280223608017
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS
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MSDS_26070_DC42463_927670-97-1
COA
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Cat. No. Product name Field of application
DC39709 Lenalidomide-Br Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs.
DC72888 Z0933M Z0933M is a potent S phase kinase-associated protein 1 (Skp1) inhibitor with Kd of 54 nM, potently inhibits Skp1-F-box protein-protein interactions with Ki value of 231 nM in FP-based in vitro competition assays.
DC72103 CC-99282 CC-99282 (Golcadomide) is an orally active cereblon (CRBN) E3 ligase modulator (CELMoD). Ikaros and Aiolos are degraded potently and specifically by CC-99282, which co-opts CRBN.
DC46257 N-Boc-SBP-0636457-OH N-Boc-SBP-0636457-OH, a ligand for E3 ubiquitin ligase, is used in the recruitment of IAP E3 ligases. N-Boc-SBP-0636457-OH can be connected to the ligand for Bcl-xL by a linker to form PROTAC Bcl-xL degrader-1.
DC44854 β-Naphthoflavone-CH2-Br β-Naphthoflavone-CH2-Br (β-NF-CH2-Br) is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br can be used to synthesize the PROTAC β-NF-JQ1.
DC42559 Piperidine-GNE-049-N-Boc Piperidine-GNE-049-N-Boc is a ligand for target protein for PROTAC of dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP.
DC42464 CRBN modulator-1 CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM.
DC42463 Thalidomide-NH-CH2-COOH Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032.
DC42462 Lenalidomide-I Lenalidomide-I (Compound 72) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570.
DC28693 CC-90009 CC-90009 is a cereblon modulator. CC-90009 specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex. This leads to the ubiquitination of certain substrate proteins and induces the proteasome-mediated degradation of certain transcription factors, including Ikaros (IKZF1) and Aiolos (IKZF3), which are transcriptional repressors in T-cells. This reduces the levels of these transcription factors, and modulates the activity of the immune system, which may include the activation of T-lymphocytes. .
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