BPR1R024|CAS 2503015-75-4|DC Chemicals

Cas No.:	2503015-75-4
Chemical Name:	Urea, N-[4-[[7-(dimethylamino)-4-quinazolinyl]oxy]phenyl]-N'-[[6-(trifluoromethyl)-3-pyridinyl]methyl]-
Synonyms:	BPR1R024
SMILES:	C1(=NC=C(CNC(=O)NC2=CC=C(C=C2)OC2=NC=NC3=CC(N(C)C)=CC=C23)C=C1)C(F)(F)F
Formula:	C₂₄H₂₁F₃N₆O₂
M.Wt:	482.46
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

Cat. No.	Product name	Field of application
DC47703	BPR1R024	BPR1R024 is an orally active and selective CSF1R inhibitor with IC50 of 0.53 nM. BPR1R024 specifically inhibits protumor M2-like macrophage survival with a minimal effect on antitumor M1-like macrophage growth.
DC8158	Pexidartinib(PLX3397)	PLX3397 is a tyrosine kinase inhibitor that potently inhibits the colony stimulating factor 1 (CSF1) receptor kinase, a driving force in the development and growth of PVNS.
DC7168	Ki20227	Ki-20227 is a highly selective c-Fms tyrosine kinase(CSF1R) inhibitor with IC50 value of 2 nM; 6 fold and > 100 fold selectivity over VEGFR2(IC50=12 nM) and c-Kit/PDGFR_beta_(IC50=451/217 nM), respectively.
DC1018	GW-2580 (GW2580)	GW2580 is a selective inhibitor of human c-FMS with IC50 of 30 nM.
DC11398	Edicotinib（JNJ-40346527）	Edicotinib（JNJ-40346527）is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity.
DC8103	BLZ-945	BLZ945 is a highly selective and brain-penetrant inhibitor of CSF1R with IC50 of 1 nM; >3200-fold higher than its affinity for other kinases.