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Caroverine hydrochloride

  Cat. No.:  DC44933   Featured
Chemical Structure
55750-05-5
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More than 5000 active chemicals with high quality for research!
Field of application
Caroverine hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 55750-05-5
Chemical Name: Caroverine hydrochloride
SMILES: O=C1N(CCN(CC)CC)C2=C(C=CC=C2)N=C1CC3=CC=C(OC)C=C3.[H]Cl
Formula: C22H28ClN3O2
M.Wt: 401.93
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Caroverine hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus[1][2][3].
Target: NMDA[1] AMPA[1]
In Vivo: Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat[4]. Animal Model: Sprague-Dawley rats of either sex (250-300 g) received impulse noise exposure[4] Dosage: 1.44 mg/rat Administration: 20 mg/mL; s.c. 1.0 mL/h for 72 h Result: Significantly protected the cochlea against impulse noise trauma.
In Vitro: Caroverine (1 μM; pretreated for 10 min) inhibits the pressor response to KCl (80 mM) and noradrenaline (1 μM) in the rat hindquarter preparation. Caroverine markedly suppresses the contraction caused by KCl (40 mM) in the rat isolated aorta[3].
References: [1]. Chen Z, et, al. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs. Audiol Neurootol. Jan-Feb 2003;8(1):49-56. [2]. Denk DM, et, al. Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol. 1997 Nov;117(6):825-30. [3]. Ishida Y, et, al. Vasorelaxant action of caroverine fumarate (a quinoxaline derivative), a calcium-blocking agent. Br J Pharmacol. 1980;71(1):343-8. [4]. Duan M, et, al. Low-dose, long-term caroverine administration attenuates impulse noise-induced hearing loss in the rat. Acta Otolaryngol. 2006 Dec;126(11):1140-7.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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