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Naspm

  Cat. No.:  DC9341   Featured
Chemical Structure
122306-11-0
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More than 5000 active chemicals with high quality for research!
Field of application
Naspm(1-Naphthylacetyl spermine) is a potent and selective Ca2+ permeable AMPA receptor(Ca-perm AMPAR) blocker. IC50 value: Target: CP-AMPAR blocker Naspm is a selective blocker of Ca(2+)-permeable GluA2-lacking AMPA receptors, reduced MNNG-induced CA1
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 122306-11-0
Chemical Name: 1-Naphthylacetylspermine
Synonyms: 1-Naphthaleneacetamide,N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-;1-Naphthylacetyl spermine;NASPM TRIHYDROCHLORIDE;Naspm trihydrochloride,N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamidetrihydrochloride;N-[3-[[4-[(3-AMinopropyl)aMino]butyl]aMino]propyl]-1-naphthaleneacetaMidetrihydrochloride;Naspm;C13674;NASPM trihydrochloride;1-naphthylacetylspermine;N-[3-[4-(3-Aminopropylamino)butylamino]propyl]naphthalene-1-acetamide;N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide;2-(1-Naphtyl)-N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]acetamide;1-NA-Spm;N-[3-[4-(3-aminopropylamino)butylamino]propyl]-2-naphthalen-1-ylacetamide;N-[3-({4-[(3-AMINOPROPYL)AMINO]BUTYL}AMINO)PROPYL]-2-(NAPHTHALEN-1-YL)ACETAMIDE;1-Naphthaleneacetamide, N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-;1-Naphthaleneacetamide, N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-;SCHEMB
SMILES: NCCCNCCCCNCCCNC(=O)CC1C2=C(C=CC=C2)C=CC=1
Formula: C22H35N4O
M.Wt: 371.54000
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
In Vitro: NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 µM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1].
References: [1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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