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GSK8175

  Cat. No.:  DC49480   Featured
Chemical Structure
1423007-82-2
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More than 5000 active chemicals with high quality for research!
Field of application
GSK8175 is a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV). GSK8175 is a sulfonamide- N-benzoxaborole analog with low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1423007-82-2
Chemical Name: 6-[(7-Chloro-1-hydroxy-3H-2,1-benzoxaborol-5-yl)-methylsulfonylamino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide
Synonyms: 6-[N-(7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide;GSK2878175;6-[(7-chloro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide;ATSKNKMCQXHIRK-UHFFFAOYSA-N;SB19803;K4P;6-(N-(7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide;6-[(7-Chloro-1-hydroxy-3H-2,1-benzoxaborol-5-yl)-methylsulfonylamino]-5-cyclopropyl-2-(4-fluoropheny
SMILES: ClC1=C2B(O)OCC2=CC(=C1)N(C1=CC2=C(C(C(NC)=O)=C(C3C=CC(=CC=3)F)O2)C=C1C1CC1)S(C)(=O)=O
Formula: C27H23BClFN2O6S
M.Wt: 568.808728456497
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_33381_DC49480_1423007-82-2
COA
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Cat. No. Product name Field of application
DC49480 GSK8175 GSK8175 is a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV). GSK8175 is a sulfonamide- N-benzoxaborole analog with low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons.
DC42458 BMS-986144 BMS-986144 is a third-generation, pan-genotype (GT) NS3/4A protease. BMS-986144 inhibits HCV replicon with EC50s of 2.3, 0.7, 1.0, 12, 8.0, and 5.8 nM for GT-1a, GT-1b, GT-2a, GT-3a, 1a R155X, and 1b D168V, respectively. BMS-986144 has the potential for the research of HCV infection.
DC9751 Velpatasvir(GS5816) Velpatasvir(GS-5816) is a potent and selective Hepatitis C virus NS5A inhibitor.
DC10104 VX222(Lomibuvir) VCH-222(Lomibuvir) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L.
DC8190 Ravidasvir hydrochloride (PPI-668) Ravidasvir(PPI-668) is a NS5A Inhibitor.
DC4121 PSI6130 PSI-6130(R 1656) is a Hepatitis C Virus Nucleoside Inhibitor. PSI-6130(R 1656) is useful for Antiviral agents.
DC10728 Pibrentasvir(ABT-530) Pibrentasvir is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50s ranging from 1.4 to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.
DC8183 Paritaprevir(Veruprevir ABT-450) NS3/4A protease inhibitor
DC10818 ABT-493(Glecaprevir) Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM.
DC8238 Danoprevir Danoprevir is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM, inhibition effect for HCV genotypes 1A/1B/4/5/6 is ~10-fold higher than 2B/3A.
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