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Rolapitant hydrochloride

  Cat. No.:  DC71780  
Chemical Structure
858102-79-1
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More than 5000 active chemicals with high quality for research!
Field of application
Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant hydrochloride does not interact with CYP3A4. Rolapitant hydrochloride shows potent anti-emetic activity in a ferret emesis model.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 858102-79-1
Chemical Name: Rolapitant hydrochloride
SMILES: O=C1N[C@]2(CN[C@@](C3=CC=CC=C3)(CO[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)CC2)CC1.[H]Cl
Formula: C25H27ClF6N2O2
M.Wt: 536.94
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC28971 Osanetant Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia.
DC28435 Orvepitant maleate Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pKi of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment.
DC11755 L-732138 A potent, selective and competitive NK1 receptor antagonist with IC50 of 2.3 nM.
DC72851 FR 113680 FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK1 neurokinin receptor.
DC72342 MEN 10207 MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.
DC72341 Septide Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a Kd value of 0.55 nM.
DC71780 Rolapitant hydrochloride Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant hydrochloride does not interact with CYP3A4. Rolapitant hydrochloride shows potent anti-emetic activity in a ferret emesis model.
DC71346 L-760735 L-760735 is a high affinity, selective and orally active NK1 receptor antagonist with an IC50 of 0.19 nM for human NK1 receptors. L-760735 exhibits anxiolytic and antidepressant-like effects.
DC49648 Imnopitant dihydrochloride Imnopitant dihydrochloride is a neurokinin NK1 receptor antagonist.
DC48921 Benzomalvin B Benzomalvin B is the less active analogs of Benzomalvin A. Benzomalvin B is weakly active against substance P.
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