SB 222200|cas 174635-69-9|DC Chemicals|Price|Buy

Cas No.:	174635-69-9
Chemical Name:	SB-222200
Synonyms:	SB 222200;SB-222200;3-Methyl-2-phenyl-N-;3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide;3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide;Lopac-S-5192;Tocris-1393;3-Methyl-2-phenyl-N-((1S)-1-phenylpropyl)quinoline-4-carboxamide;(S)-3-METHYL-2-PHENYL-N-(1-PHENYLPROPYL)-4-QUINOLINECARBOXAMIDE;SB222200;4-Quinolinecarboxamide, 3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-;C26H24N2O;(S)-3-methyl-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;SMR000326963;4-Quinolinecarboxamide, 3-methyl-2-phenyl-N-((1S)-1-phenylpropyl)-;MQNYRKWJSMQECI-QFIP;SB222200//3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxaMide;HMS3412K20;HMS3412K20;HMS3412K20;BDBM50051295;BDBM50051295;BDBM50051295;3-Methyl-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboximidic acid;3-Methyl-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboximidic acid;3-Methyl-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboximidic acid;MLS000862200;MLS000862200;MLS000862200;HMS3676K20;HMS3676K20;HMS3676K20;CHEMBL10284;CHEMBL10284;J-011023;CHEMBL10284;J-011023;4-Quinolinecarboxamide, 3-methyl-2-phenyl-N-(1-phenylpropyl)-, (S)-;J-011023;4-Quinolinecarboxamide, 3-methyl-2-phenyl-N-(1-phenylpropyl)-, (S)-;NCGC00015956-03;4-Quinolinecarboxamide, 3-methyl-2-phenyl-N-(1-phenylpropyl)-, (S)-;NCGC00015956-03;174635-69-9;NCGC00015956-03;174635-69-9;SDCCGSBI-0050088.P002;174635-69-9;SDCCGSBI-0050088.P002;DB-304732;SDCCGSBI-0050088.P002;DB-304732;NCGC00015956-06;DB-304732;NCGC00015956-06;CHEBI:92079;NCGC00015956-06;CHEBI:92079;CHEBI:92079;3-Methyl-2-phenyl-quinoline-4-carboxylic acid ((S)-1-phenyl-propyl)-amide;3-Methyl-2-phenyl-quinoline-4-carboxylic acid ((S)-1-phenyl-propyl)-amide;3-Methyl-2-phenyl-quinoline-4-carboxylic acid ((S)-1-phenyl-propyl)-amide;NCGC00015956-04;NCGC00015956-04;NCGC00015956-04;DTXSID90938540;DTXSID90938540;DTXSID90938540;Q27088710;Q27088710;NCGC00025140-01;Q27088710;NCGC00025140-01;SR-01000597583-1;NCGC00025140-01;SR-01000597583-1;Tox21_500100;SR-01000597583-1;Tox21_500100;A11361;Tox21_500100;A11361;NCGC00025140-03;A11361;BCPP000078;NCGC00025140-03;NCGC00025140-03;AS-72010;BCPP000078;BCPP000078;MLS001056793;AS-72010;AS-72010;CCG-204195;MLS001056793;MLS001056793;AKOS024456569;CCG-204195;CCG-204195;BCP02659;AKOS024456569;AKOS024456569;HMS2232O13;BCP02659;BCP02659;EX-A7938;HMS2232O13;HMS2232O13;ZGA63569;EX-A7938;EX-A7938;GTPL2131;ZGA63569;ZGA63569;NCGC00015956-11;GTPL2131;GTPL2131;HMS3260C22;NCGC00015956-11;NCGC00015956-01;NCGC00015956-11;HMS3260C22;BRD-K04414442-001-03-4;HMS3260C22;NCGC00015956-01;BRD-K04414442-001-08-3;NCGC00015956-01;BRD-K04414442-001-03-4;NCGC00025140-04;BRD-K04414442-001-03-4;BRD-K04414442-001-08-3;SR-01000597583;BRD-K04414442-001-08-3;S 5192;NCGC00025140-04;NCGC00025140-04;SR-01000597583;MFCD00944072;SR-01000597583;HY-15722;S 5192;S 5192;MFCD00944072;NCGC00260785-01;MFCD00944072;HY-15722;NCGC00015956-02;HY-15722;NCGC0026078...
SMILES:	O=C(C1C2=C([H])C([H])=C([H])C([H])=C2N=C(C2C([H])=C([H])C([H])=C([H])C=2[H])C=1C([H])([H])[H])N([H])[C@]([H])(C1C([H])=C([H])C([H])=C([H])C=1[H])C([H])([H])C([H])([H])[H]
Formula:	C₂₆H₂₄N₂O
M.Wt:	380.4816
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Potent and selective non-peptide NK3 receptor antagonist (Ki values are 4.4, > 100,000 and 250 nM For human NK3, NK1 and NK2 receptors respectively). Antihypertensive in vivo. Brain penetrant.For the detailed information of SB 222200, the solubility of SB 222200 in water, the solubility of SB 222200 in DMSO, the solubility of SB 222200 in PBS buffer, the animal experiment (test) of SB 222200, the cell expriment (test) of SB 222200, the in vivo, in vitro and clinical trial test of SB 222200, the EC50, IC50,and Affinity of SB 222200, Please contact DC Chemicals.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC46850	SB 218795	SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit.
DC28971	Osanetant	Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia.
DC28435	Orvepitant maleate	Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pKi of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment.
DC7245	SB 222200	SB 222200 is a selective, reversible and competitive antagonist of human NK-3 receptor(Ki=4.4 nM) that effectively crosses the blood-brain barrier.
DC11755	L-732138	A potent, selective and competitive NK1 receptor antagonist with IC50 of 2.3 nM.