SB 222200|cas 174635-69-9|DC Chemicals|Price|Buy

Cas No.:	174635-69-9
Chemical Name:	3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
Synonyms:	SB-222200; SB222200
SMILES:	CC1=C(C(N[C@@H](CC)C2=CC=CC=C2)=O)C(C=CC=C3)=C3N=C1C4=CC=CC=C4
Formula:	C₂₆H₂₄N₂O
M.Wt:	380.48
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Potent and selective non-peptide NK3 receptor antagonist (Ki values are 4.4, > 100,000 and 250 nM For human NK3, NK1 and NK2 receptors respectively). Antihypertensive in vivo. Brain penetrant.For the detailed information of SB 222200, the solubility of SB 222200 in water, the solubility of SB 222200 in DMSO, the solubility of SB 222200 in PBS buffer, the animal experiment (test) of SB 222200, the cell expriment (test) of SB 222200, the in vivo, in vitro and clinical trial test of SB 222200, the EC50, IC50,and Affinity of SB 222200, Please contact DC Chemicals.

MSDS

COA

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2018-0101

Cat. No.	Product name	Field of application
DC47011	Elinzanetant	Elinzanetant is a neurokinin receptors antagonist used for the research of Schizophrenia.
DC46851	Imnopitant	Imnopitant is a NK1 receptor antagonist (WO2020132716, compound 1) .
DC46850	SB 218795	SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit.
DC42312	Hemokinin 1 (mouse)	Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.
DC42311	Neurokinin A TFA	Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.
DC42048	Biotin-Substance P	Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
DC41718	[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA	[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM.
DC41717	[Lys5,MeLeu9,Nle10]-NKA(4-10)	[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM.
DC41716	GR 64349 TFA	GR 64349 is a potent and highly selective NK2 receptor peptide antagonist, with an EC50 of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3 receptors, respectively.
DC41715	GR 94800 TFA	GR 94800 TFA is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively.