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SB 218795

  Cat. No.:  DC46850   Featured
Chemical Structure
174635-53-1
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More than 5000 active chemicals with high quality for research!
Field of application
SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 174635-53-1
Chemical Name: SB 218795
Synonyms: SB 218795;methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate;(R)-[[2-Phenyl-4-quinolinyl)carbonyl]aMino]-Methylesterbenzeneaceticacid;Benzeneacetic acid, alpha-[[(2-phenyl-4-quinolinyl)carbonyl]amino]-, methyl ester, (alphaR)-;Methyl (2R)-phenyl{[(2-phenylquinolin-4-yl)carbonyl]amino}acetate;Sb 218795r;(-)-(R)-N-(α-Methoxycarbonylbenzyl)-2-phenylquinoline-4-carboxamide;(-)-(R)-N-(ALPHA-METHOXYCARBONYLBENZYL)-2-PHENYLQUINOLINE-4-CARBOXAMIDE;(R)-[[(2-PHENYL-4-QUINOLINYL)CARBONYL]AMINO]-METHYL ESTER BENZENEACETIC ACID;Benzeneacetic acid, alpha-(((2-phenyl-4-quinolinyl)carbonyl)amino)-, methyl ester, (alphar)-;Tox21_500624;Tox21_500624;Tox21_500624;Tocris-1376;Tocris-1376;Tocris-1376;SR-01000075910;SR-01000075910;SR-01000075910;BRD-K61097567-001-03-6;BRD-K61097567-001-03-6;BRD-K61097567-001-03-6;BRD-K61097567-001-08-5;BRD-K61097567-001-08-5;BRD-K61097567-001-08-5;NCGC00025131-03;NCGC00025131-03;NCGC00025131-03;GTPL5764;GTPL5764;GTPL5764;METHYL (2R)-2-PHENYL-2-[(2-PHENYLQUINOLIN-4-YL)FORMAMIDO]ACETATE;METHYL (2R)-2-PHENYL-2-[(2-PHENYLQUINOLIN-4-YL)FORMAMIDO]ACETATE;METHYL (2R)-2-PHENYL-2-[(2-PHENYLQUINOLIN-4-YL)FORMAMIDO]ACETATE;SB 218795 R;SB 218795 R;SB 218795 R;CHEMBL9843;CHEMBL9843;CHEMBL9843;HMS3412K06;HMS3412K06;HMS3412K06;HMS3267B22;HMS3267B22;HMS3267B22;SCHEMBL4459316;SCHEMBL4459316;SCHEMBL4459316;SR-01000075910-1;SR-01000075910-1;SR-01000075910-1;HY-107692;HY-107692;HY-107692;LP00624;LP00624;LP00624;NCGC00261309-01;NCGC00261309-01;NCGC00261309-01;EU-0100624;EU-0100624;EU-0100624;Q27088704;Q27088704;Q27088704;SR-01000597578-1;SR-01000597578-1;SR-01000597578-1;SB-218795;SB-218795;SB-218795;174635-53-1;174635-53-1;174635-53-1;J-011022;J-011022;NCGC00025131-04;J-011022;SMR000326950;NCGC00025131-04;NCGC00025131-04;Z2065720298;SMR000326950;SMR000326950;IUMQXQJZIHWLIN-HSZRJFAPSA-N;Z2065720298;Z2065720298;DA-77708;IUMQXQJZIHWLIN-HSZRJFAPSA-N;IUMQXQJZIHWLIN-HSZRJFAPSA-N;NCGC00025131-01;DA-77708;DA-77708;CHEBI:93066;NCGC00025131-01;NCGC00025131-01;Methyl (2R)-phenyl{[(2-phenyl-4-quinolinyl)carbonyl]amino}acetate;CHEBI:93066;CHEBI:93066;SB 218795R;Methyl (2R)-phenyl{[(2-phenyl-4-quinolinyl)carbonyl]amino}acetate;Methyl (2R)-phenyl{[(2-phenyl-4-quinolinyl)carbonyl]amino}acetate;CS-0029222;SB 218795R;SB 218795R;DTXSID80938539;CS-0029222;CS-0029222;(R)-Phenyl-[(2-phenyl-quinoline-4-carbonyl)-amino]-acetic acid methyl ester;DTXSID80938539;DTXSID80938539;methyl (2R)-2-phenyl-2-((2-phenylquinoline-4-carbonyl)amino)acetate;(R)-Phenyl-[(2-phenyl-quinoline-4-carbonyl)-amino]-acetic acid methyl ester;(R)-Phenyl-[(2-phenyl-quinoline-4-carbonyl)-amino]-acetic acid methyl ester;Benzeneacetic acid, alpha-(((2-phenyl-4-quinolinyl)carbonyl)amino)-, methyl ester, (alphaR)-;methyl (2R)-2-phenyl-2-((2-phenylquinoline-4-carbonyl)amino)acetate;methyl (2R)-2-phenyl-2-((2-phenylquinoline-4-carbonyl)amino)acetate;Methyl (R)-2-phenyl-2-(2-phen...
SMILES: COC(=O)C(C1=CC=CC=C1)NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC=CC=C4
Formula: C25H20N2O3
M.Wt: 396.4379
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC46850 SB 218795 SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit.
DC28971 Osanetant Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia.
DC28435 Orvepitant maleate Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pKi of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment.
DC11755 L-732138 A potent, selective and competitive NK1 receptor antagonist with IC50 of 2.3 nM.
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