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Orvepitant maleate

  Cat. No.:  DC28435   Featured
Chemical Structure
579475-24-4
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More than 5000 active chemicals with high quality for research!
Field of application
Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pKi of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 579475-24-4
Chemical Name: Orvepitant maleate
Synonyms: (2R,4S)-4-[(8aS)-6-oxo-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide,(Z)-but-2-enedioi;Orvepitant maleate;ORVEPITANT MALEATE - GW 823296B;(2R,4S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-[(8aS)-6-oxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-1-piperidinecarboxamide maleate;CHEMBL2105668;D09651;GW823296B;Orvepitant maleate (USAN);UNII-HAX0H28B6W;GW 823296B;Orvepitant maleate [USAN];HAX0H28B6W;Orvepitant (maleate);(2R,4S)-4-[(8aS)-6-Oxo-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide Maleate;(2R,4S)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-2-(4-fluoro-2-methylphenyl)-N-methyl-4-((S)-6-oxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)piperidine-1
SMILES: FC1C([H])=C([H])C(=C(C([H])([H])[H])C=1[H])[C@@]1([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N1C(N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1C([H])=C(C(F)(F)F)C([H])=C(C(F)(F)F)C=1[H])=O)N1C([H])([H])C([H])([H])N2C(C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H])=O.O([H])C(/C(/[H])=C(/[H])\C(=O)O[H])=O
Formula: C35H39F7N4O6
M.Wt: 744.6962
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_12488_DC28435_579475-24-4
COA
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Cat. No. Product name Field of application
DC46850 SB 218795 SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit.
DC28971 Osanetant Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia.
DC28435 Orvepitant maleate Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pKi of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment.
DC11755 L-732138 A potent, selective and competitive NK1 receptor antagonist with IC50 of 2.3 nM.
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