| DC72101 |
BT5528
|
BT5528 is a bicyclic peptide toxin conjugate, an EphA2 activator. BT5528 is made up of a bicyclic peptide and Auristatin E, is derivated from BCY6099. BT5528 shows potent anti-tumor activity without bleeding or coagulation toxicity in rats model.
|
| DC7473 |
NVP-BHG712
|
NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively. |
| DC10209 |
ALW-II-41-27
|
ALW-II-41-27 is a novel Eph receptor tyrosine kinase inhibitor, used for cancer treatment. |
| DC74406 |
WCDD301
|
WCDD301 is a high-affinity, orally available agonist of EphA4 receptor. |
| DC74405 |
Targefrin
|
Targefrin is a potent, selective antagonist targeting ligand binding domain of receptor tyrosine kinase EphA2 (EphA2-LBD), binds to EphA2-LBD with Kd of 21 nM (ITC) and shows IC50 value of 10.8 nM in biochemical assays. |
| DC50113 |
UniPR129
|
UniPR129 is a potent but problematic Eph/ephrin antagonist. UniPR129 has the potential for the research of cancer disease. |
