Cas No.: | 106083-71-0 |
Chemical Name: | 2-Morpholinol,2-(3-chlorophenyl)-3,5,5-trimethyl-, hydrochloride (1:1), (2S,3S)- |
Synonyms: | 2-Morpholinol,2-(3-chlorophenyl)-3,5,5-trimethyl-, hydrochloride (1:1), (2S,3S)-;(2S,3S)-Hydroxybupropion hydrochloride;(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol,hydrochloride;GW-353162A;(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride;(2S,3S)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride;GW 353162;Radafaxine hydrochloride;SS-hydroxybupropion hydrochloride;GW 353162A;Bupropion Morpholinol IMpurity;Bupropion Morpholinol IMpurity (HCl Salt);(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol;Radafaxine (hydrochloride) |
SMILES: | Cl.ClC1=CC(=CC=C1)C2(O)C(C)NC(C)(C)CO2 |
Formula: | C13H18NO2Cl.HCl |
M.Wt: | 292.20146 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator. |
References: | [1]. Xu H, et al. Stereoselective analysis of hydroxybupropion and application to drug interaction studies. Chirality. 2007 Mar;19(3):163-70. [2]. Bondarev ML, et al. Behavioral and biochemical investigations of bupropion metabolites. Eur J Pharmacol. 2003 Aug 1;474(1):85-93. |