| DC8798 |
Acotiamide
Featured
|
Acotiamide acts as an acetylcholinesterase inhibitor |
|
| DC10812 |
ACP-105
Featured
|
ACP-105 is a novel non-steroidal SARM (Selective Androgen Receptor Modulator). |
|
| DC11512 |
Acrizanib
Featured
|
Acrizanib（LHA510） is a potent and selective angiogenesis inhibitor and VEGFR‑2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration. |
|
| DC10492 |
ACSS2 inhibitor
Featured
|
ACSS2 inhibitor is a novel ACSS2 inhibitor. |
|
| DC11439 |
Nemorexant
Featured
|
ACT-541468 is a dual orexin receptor antagonist. |
|
| DC7997 |
ACTB-1003
Featured
|
ACTB-1003 is a potent inhibitor of FGFR1 with IC50 <10 nM in FGFR-1 biochemical assay; more information can be find in Patent WO/2007/064883A2, Example 12. |
|
| DC8191 |
Sparsentan(PS433540)
Featured
|
Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively[1]. |
|
| DC10417 |
Acumapimod (BCT197)
Featured
|
Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α. |
|
| DC20235 |
Ac-WEHD-pNA
Featured
|
Ac-WEAD-pNA is a colorimetric substrate for caspase-1 and caspase-4. |
|
| DC8476 |
ACY-738
Featured
|
ACY-738 demonstrates inhibitory activity against recombinant HDAC6 with IC50 values of 1.7 nM, with respective average selectivity over class I HDACs being 100-fold. |
|
| DC11754 |
AD 2900
Featured
|
AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively. |
|
| DC10633 |
AD80
Featured
|
AD80, a multikinase inhibitor, shows strong activity against human RET, BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM. |
|
| DC11886 |
Adavivint
Featured
|
Adavivint (SM-04690, SM 04690, SM04690) is a novel small molecule Wnt pathway inhibitor with EC50 of 3 nM in vitro |
|
| DC4155 |
Adefovir Dipivoxil
Featured
|
Adefovir Dipivoxil(Preveon, Hepsera) works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. |
|
| DC10745 |
Adelmidrol
Featured
|
Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid. |
|
| DC10685 |
Adipamidoxime(NSC 70868)
Featured
|
Adipamidoxime(NSC 70868) is a new bioactive compoud. |
|
| DC12091 |
AdipoRon hydrochloride
Featured
|
AdipoRon hydrochloride is an orally active and specific AdipoR agonist, binding to AdipoR1 and AdipoR2, with Kds of 1.8 and 3.1 μM, respectively. |
|
| DC7049 |
AdipoRon
Featured
|
AdipoRon is a novel small-molecule AdipoR agonist; binds to both AdipoR1(Kd= 1.8 uM) and AdipoR2(Kd=3.1 uM). |
|
| DC7050 |
ADL5859 HCl
Featured
|
ADL5859 agonizes δ-opioid receptor with a 1000-fold selectivity than µ- or κ-opioid receptor with Ki of 32 nM and 37 nM, respectively.ADL5859 displays weak inhibitory activity at the hERG channel with an IC50 of 78 μM. The EC50 of ADL5859 against δ opioid |
|
| DC10577 |
ADT-OH
Featured
|
ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. |
|
| DC21281 |
ADU-S100
Featured
|
ADU-S100 (MIW815) is a synthetic cyclic dinucleotide agonist of STING, elicits potent and durable anti-tumor immunity when administered IT in pre-clinical syngeneic tumor models.. |
|
| DC11097 |
ADX-102 (Reproxalap;NS-2)
Featured
|
ADX-102 (Reproxalap, NS-2) is a novel small molecule immunomodulator that covalently binds aldehydes including malondialdehyde and 4-hydroxynonenal, which have been shown to mediate inflammatory pain; DX-102 is a promising agent for the treatment of dry eye disease. |
|
| DC8087 |
ADX 47273
Featured
|
ADX-47273 is a novel, potent and selective metabotropic glutamate receptor 5 allosteric modulator with an EC50 of 170 nM. |
|
| DC10465 |
ADX-88178
Featured
|
ADX-88178 is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor. |
|
| DC7703 |
AEBSF-hydrochloride
Featured
|
AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor. |
|
| DC5113 |
AEE-788 (NVP-AEE788)
Featured
|
AEE788 is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2. |
|
| DC21988 |
AER-271
Featured
|
AER-271 (AER271) is a selective, small molecule inhibitor of aquaporin-4 (AQP4), the prodrug of AER-270 with enhanced solubility. |
|
| DC21989 |
AES-135
Featured
|
AES-135 (AES135) is a novel HDAC inhibitor that biochemically inhibits HDACs 3, 6, 8 and 11 with IC50 values of 190-1100 nM. |
|
| DC8355 |
Adjudin (AF-2364)
Featured
|
AF-2364, an analogue of Lonidamine (LND), had a contraceptive effect when orally administered to adult Sprague–Dawley rats. |
|
| DC7783 |
AF-353(Ro-4)
Featured
|
AF-353 is a novel, orally bioavailable, highly potent and selective P2X3/P2X2/3 receptor antagonist. |
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