Cat. No. | Product name | CAS No. |
DC25065 |
NIBR 0213
Featured
A potent, selective, orally active S1P1 antagonist with IC50 of 2.5 nM Ca2+ mobilization assays, without activity on S1P2, S1P3 and S1P4 (IC50>10 uM). |
1233332-14-3 |
DC20654 |
AM-0902
Featured
A potent, selective, orally active TRPA1 channel antagonist with IC50 of 71 and 131 nM for rTRPA1 and hTRPA1 in Ca2+ flux assays respectively, without agonist activity (EC50>40 uM). |
1883711-97-4 |
DC23599 |
PF-0346275
Featured
PF-0346275 is a potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM). |
1173239-39-8 |
DC24182 |
Nilotinib monohydrochloride monohydrate
Featured
A potent, selective, orally available inhibitor of both native and mutant Bcr-Abl with IC50 of 20-80 nM. |
923288-90-8 |
DC11688 |
Avacopan
Featured
Avacopan is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM. |
1346623-17-3 |
DC24048 |
NVP-BKM120 hydrochloride
Featured
A potent, selective, orally bioavailable inhibitor of class I PI3K isoforms with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/β/δ/γ, respectively. |
1312445-63-8 |
DC23552 |
AS-2444697 HCl
Featured
A potent, selective, orally bioavailable IRAK-4 inhibitor that potently inhibits human and rat IRAK-4 activity with subnanomolar order, >30-fold selectivity over IRAK-1. |
1287665-60-4 |
DC21607 |
SB-649868
Featured
SB-649868 is a potent and selective orally active orexin (OX) 1 and OX2 receptor antagonist (pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively). |
380899-24-1 |
DC11748 |
LY2033298
Featured
LY2033298 is a robust allosteric potentiator that is highly selective for the human M4 muscarinic acetylcholine receptor subtype. LY2033298 enhances inhibition by oxotremorine of light-induced phase shifts in hamster circadian activity rhythms. |
886047-13-8 |
DC11691 |
NSC95397
Featured
A potent, selective, reversible Cdc25 dual specificity phosphatase inhibitor with Ki of 32/96/40 nM for Cdc25A/B/C, respectively. |
93718-83-3 |
DC11978 |
SB 265610
Featured
SB-265610 is a selective, competitive, nonpeptide and allosteric CXCR2 antagonist. |
211096-49-0 |
DC21321 |
ML349
Featured
A potent, specific acyl protein thioesterase 2 (APT-2, LYPLA2) inhibitor with IC50 of 144 nM and Ki of 120 nM, >20-fold selectivity over APT-1 and serine hydrolase enzyme family. |
890819-86-0 |
DC23494 |
GRI 977143
Featured
A potent, specific and nonlipid agonist of LPA2 receptor with EC50 of 3.3 uM, does not activate any of the other LPA GPCRs (>10 uM). |
325850-81-5 |
DC24105 |
MK-0591(Quiflapon )
Featured
A potent, specific and orally active 5-Lipoxygenase-activating protein (FLAP) inhibitor with IC50 of 1.6 nM in FLAP binding assay. |
136668-42-3 |
DC21807 |
VU 0465350
Featured
VU 0465350 is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM; shows no activity for ALK2/4/5, also shows affinity for TGFBR2, VEGFR2 and AMPK; blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy. |
1414843-61-0 |
DC21794 |
VH 298
Featured
A potent, specific cell-active VHL E3 ubiquitin ligase inhibitor that inhibits VHL/HIF-α interaction with Kd of 90 nM in ITC assays. |
2097381-85-4 |
DC24007 |
R-1479
Featured
A potent, specific inhibitor of HCV NS5B polymerase and HCV replication (IC50=1.28 uM, replicon assay). |
478182-28-4 |
DC11871 |
MMV019313
Featured
MMV019313 (MMV 019313, MMV-019313) is a potent, specific malaria bifunctional farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) inhibitor with IC50 of 330 nM; shows no activity against human FPPS or GGPPS (>200 uM); exhibits distinct modes of inhibition compared with bisphosphonates, inhibits P. falciparum growth with EC50 of 268 nM, overexpression and an S228T variant of PfFPPS/GGPPS confer resistance to MMV 019313. |
902630-14-2 |
DC24060 |
YM-155 hydrochloride
Featured
A potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM. |
355406-09-6 |
DC22865 |
CK-0106023
Featured
A potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM. |
336115-72-1 |
DC20890 |
ChoK-α inhibitor CK37
Featured
A potent, specific, competitive inhibitor of choline kinase-α (Chok-α) by targeting the choline binding site; significantly increases LC3II expression in MCF-7 and MCF-7/TAM cells, increases the size and number of autophagosome, causes MCF-7 and MCF-7/TAM |
1001478-90-5 |
DC26079 |
GW 803430
Featured
A potent, specific, orally active melanin concentrating hormone receptor 1 (MCHR1) inhibitor with kI of 3.8 nM, >100-fold selectivity over a battery of GPCRs, ion channels and enzymes. |
515141-51-2 |