| DC60281 |
Bucolome
Featured
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Bucolome is a CYP2C9 inhibitor, used as an uricosuric agent or anti-inflammatory agent. |
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| DC60282 |
Potassium Channel Activator 1
Featured
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Carbamic acid, N-[2,4-dimethyl-6-(4-morpholinyl)-3-pyridinyl]-, phenylmethyl ester is a new invention for treating, one or more disorders or conditions wherein the dopaminergic system is disrupted, such as one or more disorders or conditions independently selected from the group consisting of: schizophrenia and other psychotic states; mood disorders ADHD; aggression; movement disorders. |
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| DC60283 |
CDDO-TFEA
Featured
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| DC60284 |
GN13
Featured
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GN13 is a potent, selective, and cell-permeable inhibitor of Gαs, with a strong binding affinity for the active, GTP-bound state of Gαs (KD = 0.19 μM). Its high selectivity and ability to penetrate cells make it a powerful tool for studying Gαs signaling in both basic research and potential therapeutic applications. |
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| DC60285 |
GD20
Featured
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GD20 is a cell-permeable, nucleotide-inactive-state-selective inhibitor of Gαs, with high selectivity over other G protein subfamilies. GD20 inhibits Gαs steady-state GTPase activity with IC50 of 1.15 μM.
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| DC60286 |
(R)-69
Featured
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(R)-69 is a 5-HT2AR partial agonists with EC50 of 41 nM, and shows 4.6-fold/29-fold selectivity over 5HT2BR/5HT2CR. (R)-69 has substantial brain permeability in mouse pharmacokinetic studies and dose not possess locomotor-stimulating or reinforcing activity.
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| DC60288 |
(R)-70
Featured
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(R)-70 is a 5-HT2AR partial agonists with EC50 of 110 nM, and shows 6.4-fold/51-fold selectivity over 5HT2BR/5HT2CR. (R)-70 has substantial brain permeability in mouse pharmacokinetic studies and dose not possess locomotor-stimulating or reinforcing activity.
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| DC60289 |
Antitubercular agent-30
Featured
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Antitubercular agent-30 is an antibacterial agent against Mycobacterium tuberculosis (MIC=50 μg/mL). Antitubercular agent-30 has little cytotoxic effect on murine macrophage cells (LD85=~100 μg/mL). |
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| DC60291 |
WAY-620645
Featured
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| DC60292 |
WAY-115880
Featured
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| DC60294 |
SphK1&2-IN-1
Featured
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SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability. |
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| DC60290 |
c-Met-IN-15
Featured
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c-Met-IN-15 (compound S3) is a c-Met kinase inhibitor. c-Met-IN-15 inhibits c-Met kinase activity of 21.1% at the concentration of 10 μM. |
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| DC60295 |
PAZ-417
Featured
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| DC60296 |
WAY-620057
Featured
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| DC60297 |
CL-302396
Featured
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| DC60298 |
WAY-349858
Featured
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| DC60301 |
WAY659100
Featured
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| DC60302 |
WAY641966
Featured
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WAY-641966 is a anti-prion agent. |
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| DC60303 |
WAY320461
Featured
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WAY-320461 is a FAK inhibitor. |
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| DC60305 |
WAY328178
Featured
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| DC60306 |
ESI-08
Featured
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ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2. |
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| DC60307 |
WAY323096
Featured
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| DC60308 |
5-HT3 antagonist 5
Featured
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5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice[1]. |
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| DC60309 |
PKCiota-IN-49
Featured
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PKCiota-IN-2 is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively. |
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| DC60299 |
2-chloroprop-2-en-1-amine;hydrochloride
Featured
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| DC60304 |
TRPM4-IN-2
Featured
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TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer[1][2]. |
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| DC60310 |
(3S,6R)-Lateritin
Featured
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Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), isolated from the mycelial cake of Gibberella lateritium IFO 7188[1]. Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candida albicans[2]. |
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| DC60312 |
CL-802
Featured
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| DC60313 |
UT-34
Featured
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UT-34 is a potent, selective and orally active second-generation pan-androgen receptor (AR) antagonist and degrader with IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively. UT-34 binds to ligand-binding domain (LBD) and function-1 (AF-1) domains and requires ubiquitin proteasome pathway to degrade the AR. UT-34 has anti-prostate cancer efficacy[1][2]. |
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| DC72144 |
TH-Z145
Featured
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TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 210 nM). |
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