| DC72076 |
AZD5462
Featured
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AZD5462 is a selective oral allosteric relaxin family peptide receptor 1 (RXFP1) agonist with pEC50 of 7.8. AZD5462 has better kinetic solubility and shows much improved metabolic stability compared to AZ7976 in vitro. |
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| DC72081 |
Astrophloxine
Featured
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Astrophloxine is a fluorescent imaging probe capable of targeting antiparallel dimers. Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples of Alzheimer's disease (AD) mice. |
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| DC72098 |
GSK626616
Featured
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GSK-626616 is a dual-specificity tyrosine-regulated kinase (DYRK3) inhibitor with an IC50 of 0.7 nM which is a potential therapy for the treatment of anemia. |
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| DC72103 |
CC-99282
Featured
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CC-99282 (Golcadomide) is an orally active cereblon (CRBN) E3 ligase modulator (CELMoD). Ikaros and Aiolos are degraded potently and specifically by CC-99282, which co-opts CRBN. |
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| DC72110 |
RPT193
Featured
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RPT193 is an orally active inhibitor of CCR4, blocks the recruitment of Th2 inflammatory immune cells into inflamed tissues. RPT193 can be used for allergic inflammation in atopic dermatitis, asthma, and other diseases research. |
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| DC72116 |
Chiauranib
Featured
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Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy. |
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| DC60258 |
QN523
Featured
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QN523 exhibits potent cytotoxicity in pancreatic cancer cell lines (IC50 of 0.11 μM in MIA PaCa-2 cells) and significantly delays growth of MIA PaCa-2 xenograft in NOD/SCID mice without systemic toxicity.
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| DC60260 |
ML901
Featured
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ML901 is a specific reagent that hijacks a single aminoacyl transfer RNA (tRNA) synthetases (aaRSs) in the malaria parasite Plasmodium falciparum. ML901 inhibits the growth of the malaria parasite Plasmodium falciparum in vitro and in animals but was not toxic to human cells.
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| DC60261 |
ERX-41
Featured
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ERX-41 is a potent therapeutic agent targeting lysosomal acid lipase A (LIPA) and shows the mechanism of action (disruption of protein folding and induction of ER stress) that may have utility in treating patients with TNBC or other multiple solid tumors.
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| DC60263 |
CID661578
Featured
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CID661578 is a potent inducer of β-cell regeneration, which boosts protein synthesis and regeneration by blocking MNK2 from binding eIF4G in the translation initiation complex at the mRNA cap.
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| DC60264 |
NKTP-3
Featured
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NKTP-3 is a potent, selective, biostable, and cell-permeable cyclic d-peptide that targets NRP1 and KRASG12D with binding affinity of 116.28 nM and 50.34 nM, respectively. NKTP-3 shows good biostability and a strong cellular uptake ability and further demonstrated its antitumor effect on lung cancer with the KRASG12D mutation in vitro and in vivo.
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| DC60265 |
IGUANA-1
Featured
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IGUANA-1 is an isoform-selective guanidinyl antagonists of ALDHs, which exhibits proteome-wide target specificity and selectively blocks the growth of colon cancer spheroids and organoids.
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| DC60266 |
S3-15
Featured
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S3-15 selectively interrupts soluble RANKL-RANK interaction and without interfering with the membrane RANKL-RANK interaction. S3-15 exhibits anti-osteoporotic effects without causing immunosuppression.
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| DC60267 |
JZ128
Featured
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JZ128 is a potential, irreversible, selective inhibitor of PKN3 with IC50 of 120 nM and shows a narrow kinome inhibition spectrum. JZ128 is used as a tool compound to identify novel potential PKN3 substrates.
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| DC60268 |
Compound 16 (UNC-CA94)
Featured
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Compound 16 (UNC-CA94) is a reversible inhibitor of PKN3 with IC50 of 14 nM. Compound 16 (UNC-CA94) is a potential tool compound to study the cell biology of PKN3.
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| DC60271 |
Jun9-62-2R (dichloroacetamide)
Featured
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Jun9-62-2R (dichloroacetamide) is a selective covalent Mpro inhibitor with IC50 of 0.43 μM and viral replication with EC50 of 2.05 μM in Caco2-hACE2 cells. Jun9-62-2R (dichloroacetamide) is highly selective toward Mpro and does not inhibit the host calpain I, cathepsins B, K, L, caspase-3, and trypsin. The widely used antibiotic chloramphenicol contains the dichloroacetamide, suggesting Jun9-62-2R might be tolerated in vivo.
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| DC60270 |
D11 (NSC 379099)
Featured
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D11 is a potent and selective inhibitor of protein kinase CK2 with Ki of 5 nM.
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| DC60272 |
Comopound X1 (Xist)
Featured
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Comopound X1 (Xist) binds the non-coding RNA prototype Xist, specifically the RepA motif, with Kd of 0.4 μM. X1 binding reduces the conformational space of RepA, displaces cognate interacting protein factors (PRC2 and SPEN), suppresses histone H3K27 trimethylation, and blocks initiation of X-chromosome inactivation.
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| DC60269 |
WC36
Featured
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WC36 is a novel nonlipidic inhibitor of the lipid-SH2 domain interaction. WC36 is effective against RAS-mutated HL-60 AML cells that shows de novo resistance to entospletinib.
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| DC60273 |
3,5-Dimethoxyaniline
Featured
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| DC60287 |
Sitagliptin phosphate
Featured
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Sitagliptin, also known as MK-0431, is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts. Sitagliptin is believed to exert its actions in patients with type 2 diabetes mellitus by slowing the inactivation of incretin hormones. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner. Sitagliptin demonstrates selectivity for DPP-4 and does not inhibit DPP-8 or DPP-9 activity in vitro at concentrations approximating those from therapeutic doses. |
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| DC60293 |
Potassium osmate(VI) dihydrate
Featured
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| DC60300 |
2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene
Featured
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| DC60274 |
Tematropium methylsulfate
Featured
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Tematropium(CDDD3602) is a soft anticholinergics. |
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| DC60275 |
CDC801
Featured
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CDC801 is a potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α (TNF-α) inhibitor with IC50 of 1.1 μM and 2.5 μM, respectively. |
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| DC60276 |
APOL1-IN-1
Featured
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APOL1-IN-1 is a apolipoprotein L1 (APOL1) inhibitor extracted from patent WO2020131807A1 compound 87. APOL1-IN-1 can be used for the research of focal segmental glomerulosclerosis (FSGS) and non-diabetic kidney disease (NDKD)[1]. |
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| DC60277 |
Eed226-cooh
Featured
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| DC60278 |
RMC-0331
Featured
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| DC60279 |
ART812
Featured
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ART-812 is a potent inhibitor of DNA polymerase Polθ (also known as Pol theta or POLQ), with an IC50 value of 7.6 nM. This indicates that ART-812 effectively inhibits the enzymatic activity of Polθ at low nanomolar concentrations. Polθ is a key enzyme involved in the microhomology-mediated end joining (MMEJ) pathway, which is an error-prone DNA repair mechanism. |
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| DC60280 |
CCG 203769
Featured
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CCG-203769 is a selective G protein signaling (RGS4) inhibitor, which blocks the RGS4-Gαo protein-protein interaction in vitro with an IC50 of 17 nM. |
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