| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC65128 | 5-BROMO-2-(4-BOC-PIPERAZIN-1-YL)PYRIMIDINE Featured |
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| DC65129 | CPD3325-A8 Featured |
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| DC65130 | DIPHENYL ((6-METHYLPYRIDIN-2-YL)(PHENYLAMINO)METHYL)PHOSPHONATE Featured |
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| DC65131 | 6-Bromo-1,5-dimethylpyrimidine-2,4(1H,3H)-dione Featured |
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| DC65132 | 2-chloro-6-methyl-4-(trifluoromethyl)nicotinonitrile Featured |
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| DC65133 | (aS)-a-methyl-1H-Indole-3-ethanamine Featured |
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| DC65134 | 6-bromo-3-chloro-7-fluoro-2-methyl-1,5-naphthyridin-4-ol Featured |
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| DC65135 | 3-(3-Fluorophenyl)-5-nitro-4-pyridinamine Featured |
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| DC65136 | N-(5-bromopyridin-3-yl)-3-methylbutanamide Featured |
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| DC65137 | 5-(3-fluorophenyl)pyridine-3,4-diamine Featured |
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| DC65138 | CPD109174-A4 Featured |
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| DC65139 | 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 1,4-dihydro-5-methyl- (9CI) Featured |
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| DC65140 | IHMT-PI3Kδ-372 S-isomer Featured |
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| DC65141 | METHYL 5-CHLORO-7-(TRIFLUOROMETHYL)THIENO[3,2-B]PYRIDINE-3-CARBOXYLATE Featured |
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| DC65142 | 6-Methoxynicotinaldehyde Featured |
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| DC65143 | 2-(Piperazin-2-yl)acetonitrile dihydrochloride Featured |
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| DC86601 | Lipid 8 Featured | Lipid 8 iLNPs were used to deliver CRISPR-Cas9 mRNA and sgRNA which targeted to the PLK1 gene. The safety and excellent intracerebral diffusion performance of lipid 8 iLNPs ensured that the survival of murine glioblastoma multiforme (GBM) mice was extended. The median survival was extended by approximately 50% and the overall survival was increased by 30%. The treatment of metastatic adenocarcinoma was executed by the EGFRtargeted lipid 8 iLNPs. These iLNPs possessed the ability of tumor targeting, which could increase the accumulation of CRISPR-Cas9 mRNA and sgRNA within the tumor cells. After a single intraperitoneal administration, 80% PLK1 gene was edited and the overall survival of mice with high-grade ovarian cancer malignant ascites was enhanced by 80% . These results demonstrate the clinical potential of CRISPR-Cas9 gene editing system can be delivered by iLNPs for treating tumors, and provide new ideas for tumor gene therapy. |
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| DC65144 | CPD10000-A3 Featured |
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| DC65145 | 2-Morpholinecarboxamide, N-(3-chloro-4-cyanophenyl)-, (2R) Featured |
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| DC65146 | CPD108743 int Featured |
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| DC65147 | CPD1725-A3 Featured |
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| DC65149 | CPD3236 Featured |
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| DC65150 | 5-Pyrimidinemethanamine, α-(4-fluorophenyl)-α-methyl-2-(1-piperazinyl)- Featured |
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| DC65151 | CPD1639-A5 Featured |
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| DC65152 | CPD0948 Featured |
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| DC65153 | Phocaecholic acid Featured |
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| DC65154 | Cholan-24-oic acid, 3,7,12,23-tetrahydroxy-, (3α,5β,7α,12α,23S)- (9CI) Featured |
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| DC65155 | beta-Phocaecholsaeure, 3alpha,7alpha,23-Trihydroxy-cholansaeure Featured |
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| DC65156 | 3,7,12,23-tetrahydroxycholan-24-oic acid Featured |
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| DC65157 | CPD2049-Amine Featured |
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