| DC11575 |
E3 Ligand-Linker Conjugate 9
Featured
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An E3 ligase ligand-linker conjugate for PROTAC. |
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| DC11572 |
E3 Ligand-Linker Conjugate 6
Featured
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An E3 ligase ligand-linker conjugate for PROTAC.. |
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| DC11573 |
E3 Ligand-Linker Conjugate 7
Featured
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An E3 ligase ligand-linker conjugate for PROTAC.. |
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| DC11574 |
E3 Ligand-Linker Conjugate 8
Featured
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An E3 ligase ligand-linker conjugate for PROTAC.. |
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| DC22869 |
E3 Ligand-Linker Conjugate 3(E3 Ligase Ligand-Linker Conjugates 19)
Featured
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An E3 ligase ligand-linker conjugate for PROTAC. |
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| DC26084 |
LE-135
Featured
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LE135 is a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels. |
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| DC24168 |
(R)-(-)-Ibuprofen
Featured
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An enantiomer of Ibuprofen that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids. |
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| DC23914 |
Thymalfasin
Featured
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An immunoactive peptide that has been shown to inhibit cell proliferation and induce apoptosis in human leukemia, non-small cell lung cancer, melanoma, and other human cancers. |
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| DC1001 |
FK-506 (Tacrolimus)
Featured
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Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties. |
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| DC22995 |
IRES-J007
Featured
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IRES-J007 ia an improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242. |
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| DC6311 |
Pomalidomide
Featured
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An inhibitor of LPS-induced TNFαrelease.Pomalidomide is thalidomide derivative that displays inhibition of LPS-induced TNFα release. Shows immunomodulator and anticancer effects. |
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| DC24177 |
Mitiglinide calcium hydrate
Featured
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An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells. |
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| DC22612 |
Afatinib
Featured
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An irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively. |
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| DC11640 |
PK-11195
Featured
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PK 11195 is a ligand of translocator protein. It targets Leishmania chemotherapy (IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively). |
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| DC11911 |
Rovazolac
Featured
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Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1. |
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| DC24069 |
CI-947
Featured
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An orally active adenosine receptor agonist that can induce acute cardiovascular toxicity and coronary vascular injury in vivo.. |
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| DC23019 |
PACMA 31
Featured
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An orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI. |
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| DC21242 |
LM11A-31 dihydrochloride
Featured
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An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors. |
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| DC24008 |
Eperezolid
Featured
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An oxazolidinone antibiotic that possesses potent antimicrobial activity in vitro and in vivo.. |
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| DC20418 |
InS3-54
Featured
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An STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3. |
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| DC7815 |
Crisaborole(AN-2728)
Featured
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AN-2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines. |
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| DC9827 |
AN3365(Epetraborole)
Featured
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AN3365 is a first-in-class antibiotic that demonstrates potent activity across a wide spectrum of Gram-negative bacteria, including those resistant to many other antibiotics. |
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| DC8029 |
ANA-12
Featured
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ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice. |
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| DC23543 |
ANA975
Featured
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ANA975 is an oral prodrug of the TLR-7 agonist Isatoribine (ANA245. |
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| DC8322 |
Anacardic Acid
Featured
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Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (pCAF) with IC50 values of 8.5 and 5 µM, respectively. |
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| DC7804 |
Anacetrapib(MK0859)
Featured
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Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3. |
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| DC7357 |
Anamorelin
Featured
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Anamorelin(RC1291; ONO-7643) is a synthetic orally active ghrelin receptor agonist which is under development for the management of non-small lung cancer associated cachexia/anorexia. |
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| DCAPI1425 |
Anastrozole
Featured
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Anastrozole is known to inhibit the CYP19 enzyme (aromatase, IC50 = 15 nM) that converts androgens to estrogens. Anastrozole has been seen to reversibly bind to the CYP19 enzyme through competitive inhibition. |
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| DC11649 |
Jamaicin (AnCoA4)
Featured
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AnCoA4 (AnCoA-4, AnCoA 4) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM. |
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| DC8122 |
Andarine (GTX-007,S-4)
Featured
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GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity. |
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