Cat. No. | Product name | CAS No. |
DC65130 | DIPHENYL ((6-METHYLPYRIDIN-2-YL)(PHENYLAMINO)METHYL)PHOSPHONATE Featured | 614750-85-5 |
DC65131 | 6-Bromo-1,5-dimethylpyrimidine-2,4(1H,3H)-dione Featured | 1609259-61-1 |
DC65132 | 2-chloro-6-methyl-4-(trifluoromethyl)nicotinonitrile Featured | 13600-48-1 |
DC65133 | (aS)-a-methyl-1H-Indole-3-ethanamine Featured | 7795-51-9 |
DC65134 | 6-bromo-3-chloro-7-fluoro-2-methyl-1,5-naphthyridin-4-ol Featured | 2074703-10-7 |
DC65135 | 3-(3-Fluorophenyl)-5-nitro-4-pyridinamine Featured | 1884188-39-9 |
DC65136 | N-(5-bromopyridin-3-yl)-3-methylbutanamide Featured | 1266227-13-7 |
DC65137 | 5-(3-fluorophenyl)pyridine-3,4-diamine Featured | 1214358-61-8 |
DC65138 | CPD109174-A4 Featured | 1391540-47-8 |
DC65139 | 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 1,4-dihydro-5-methyl- (9CI) Featured | 55904-62-6 |
DC65140 | IHMT-PI3Kδ-372 S-isomer Featured | 2429889-61-0 |
DC65141 | METHYL 5-CHLORO-7-(TRIFLUOROMETHYL)THIENO[3,2-B]PYRIDINE-3-CARBOXYLATE Featured | 648859-81-8 |
DC65142 | 6-Methoxynicotinaldehyde Featured | 65873-72-5 |
DC65143 | 2-(Piperazin-2-yl)acetonitrile dihydrochloride Featured | 2158301-19-8 |
DC86601 |
Lipid 8
Featured
Lipid 8 iLNPs were used to deliver CRISPR-Cas9 mRNA and sgRNA which targeted to the PLK1 gene. The safety and excellent intracerebral diffusion performance of lipid 8 iLNPs ensured that the survival of murine glioblastoma multiforme (GBM) mice was extended. The median survival was extended by approximately 50% and the overall survival was increased by 30%. The treatment of metastatic adenocarcinoma was executed by the EGFRtargeted lipid 8 iLNPs. These iLNPs possessed the ability of tumor targeting, which could increase the accumulation of CRISPR-Cas9 mRNA and sgRNA within the tumor cells. After a single intraperitoneal administration, 80% PLK1 gene was edited and the overall survival of mice with high-grade ovarian cancer malignant ascites was enhanced by 80% . These results demonstrate the clinical potential of CRISPR-Cas9 gene editing system can be delivered by iLNPs for treating tumors, and provide new ideas for tumor gene therapy. |
2226547-25-5 |
DC65144 | CPD10000-A3 Featured | 2230840-12-5 |
DC65145 | 2-Morpholinecarboxamide, N-(3-chloro-4-cyanophenyl)-, (2R) Featured | 1887164-96-6 |
DC65146 | CPD108743 int Featured | 2259835-10-2 |
DC65147 | CPD1725-A3 Featured | 37949-03-4 |
DC65149 | CPD3236 Featured | 1191265-32-3 |
DC65150 | 5-Pyrimidinemethanamine, α-(4-fluorophenyl)-α-methyl-2-(1-piperazinyl)- Featured | 1704492-10-3 |
DC65151 | CPD1639-A5 Featured | 1445993-96-3 |