| DC67308 |
CbzNH-PEG1-Br
Featured
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| DC67309 |
H2N(CH2)3N(tert-butoxycarbonyl)(CH2)4NH2
Featured
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| DC67310 |
1,4-Piperazinediethylamine
Featured
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| DC67311 |
1-Propanaminium, 2,3-dihydroxy-N,N,N-trimethyl-, chloride (1:1), (2R)-
Featured
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| DC67312 |
1-Propanethiol, 3-(diMethylaMino)-, hydrochloride
Featured
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| DC67313 |
6-Oxohexyl 2-hexyldecanoate
Featured
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| DC60799 |
TDI-015051
Featured
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TDI-015051 is a first-in-class non-covalent inhibitor of the viral guanine-N7 methyltransferase (MTase) NSP14 with Kd of 61 pM and IC50 ≤ 0.15 nM, respectively. |
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| DC60801 |
VIP36
Featured
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VIP36 is a peripherally restricted cannabinoid receptor type 1 (CB1) agonist with Ki of 22 nM and exerts analgesic efficacy through peripheral CB1 receptors and shows limited analgesic tolerance. |
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| DC60802 |
P6CIT
Featured
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P6CIT is a cationic lipid for targeted mRNA delivery to pancreatic ductal adenocarcinoma (PDAC). Pan-tgt (P6CIT) LNP could specifically deliver mRNA to immune cells in PDAC tissues, including dendritic cells (DCs), macrophages, natural killer (NK) cells, and T cells. |
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| DC60803 |
BRINP2-related peptide (BRP)
Featured
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BRINP2-related peptide (BRP) is a 12-mer peptide, as a potent anorexigenic peptide. BRP demonstrates significant appetite-suppressing effects in mice and pigs, and triggers FOS activation in the hypothalamus. |
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| DC60804 |
Ferfluor-1
Featured
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Ferfluor-1 is a novel 1,3,4-thiadiazole-functionalized druglike ferrostatin analogue as a ferroptosis inhibitor and photoluminescent indicator. Ferfluor-1 shows superior anti-ferroptosis potency, favorable BBB permeability and in vivo activity against stroke and Parkinson's disease. |
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| DC60805 |
YK-2168
Featured
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YK-2168 is a differentiated selective CDK9 inhibitor with IC50 of 5.9 nM, demonstrating 72.5-fold and 45.2-fold selectivity over CDK1 and CDK2, respectively. YK-2168 achieves superior CDK9 selectivity over AZD4573 and comparable selectivity to BAY1251152. |
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| DC60806 |
PF-07265028
Featured
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PF-07265028 is a selective inhibitor of hematopoietic progenitor kinase 1 (HPK1) with Ki<0.05 nM and represents >280-fold improvement in biochemical potency while maintaining a comparable lipophilicity. |
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| DC60807 |
YB-3−17
Featured
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YB-3−17 is a novel bifunctional molecule, robustly inhibits mTOR (IC50 of 0.22 nM) and selectively degrades GSPT1 (DC50 of 5 nM). YB-3−17 degrades GSPT1 selectively without affecting GSPT2 or SNUPN. YB-3−17 shows significant off-target inhibition of kinases like FGR, CSF1R, LCK, or LYN, unlike MLN0128. |
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| DC60808 |
503O8,12
Featured
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503O8,12 is a branched-tail ionizable lipidoid mRNA delivery with immune cell specificity. In vivo, 503O8,12 demonstrated spleen-tropism (≈50% signal) with significant lung targeting (≈35%) after IV administration. Flow cytometry revealed preferential transfection of lung lymphoid cells (NK/dendritic cells) over endothelial/epithelial cells. It showed no overt toxicity in histology but induced transient pro-inflammatory cytokines. |
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| DC65412 |
Acuitas Lipid III-2
Featured
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Acuitas Lipid III-2 is an ionizable amine lipid with two identical ester tails adjacent to C6 position relative to amine from patent:WO2017075531A1 with the similar activity as ALC-0315. The head of lipid is propanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle. |
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| DC67316 |
S-2238 H-D-Phe-Pip-Arg-pNA acetate
Featured
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| DC67317 |
S-2222 N-benzoyl-ile-glu-gly-arg P-nitroanilide acetate
Featured
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| DC67318 |
S-2366 Pyr-Pro-Arg-pNA hydrochloride
Featured
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| DC67319 |
S-2403 PyroGlu-Phe-Lys-pNA hydrochloride
Featured
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| DC67320 |
S-2732 Suc-lle-Glu (y-Pip) -Gly-Arg-pNA hydrochloride
Featured
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| DC60809 |
6Ac1-C12
Featured
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The 6Ac1-C12 LNPs exhibit a pKa of ~6.0, enabling pH-responsive endosomal escape. They demonstrate high stability (maintaining ~100 nm size for 30 days at 4°C) and efficient mRNA encapsulation. With slightly negative surface charge, these nanoparticles show serum resistance. The liver-targeted formulation (4-component) achieves 98% hepatic mRNA expression, primarily in endothelial (60%) and Kupffer cells. The cholesterol-free 3-component lung-targeted version eliminates hepatic accumulation while enabling 71% transfection in pulmonary endothelial cells. Both formulations maintain structural integrity post-dialysis and show low cytotoxicity, with lung-targeted LNPs exhibiting reduced lipoprotein adsorption for enhanced organ specificity. |
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| DC60810 |
Lipid head 503 (1,3-Propanediamine, N,N'-bis(2-aminoethyl)-N,N'-dimethyl-)
Featured
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| DC60815 |
TH35
Featured
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TH35 is a novel class of CRBN-recruiting cGAS-targeting PROTAC degrader with IC50 of 1.8 and 4.8 μM,in THP1-Lucia ISG and RAW-Lucia ISG cells, respectively. TH35 exhibits strong anti-inflammatory effects in the DSS-induced UC mice model. |
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| DC60816 |
UNC9426
Featured
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UNC9426 is a novel and potent TYRO3 inhibitor with IC50 of 2.1 nM and Ambit selectivity score (S50 (1.0 μM) = 0.026), respectively. UNC9426 shows favorable pharmacokinetic properties in mice. |
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| DC67321 |
1,3,5-Tribromoadamantane
Featured
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| DC60817 |
AM-9747
Featured
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AM-9747 is an MTA-cooperative PRMT5 inhibitor with IC50 of 9.5 nM in the MTAP-del viability assay and shows outstanding 75-fold selectivity over the corresponding isogenic MTAP-WT cellular viability. AM-9747 also shows a significant oral antitumor effect in mouse models employing PDXs. |
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| DC67322 |
GL67 pentahydrochloride
Featured
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GL67 (N4-Spermine cholesteryl carbamate) in its pentahydrochloride form is a cationic lipid with versatile applications in the delivery of nucleic acid agents, vaccines, and gene transfection, owing to its efficient encapsulation and transport capabilities.GL67 (N4-Spermine cholesteryl carbamate) in its pentahydrochloride form is a cationic lipid with versatile applications in the delivery of nucleic acid agents, vaccines, and gene transfection, owing to its efficient encapsulation and transport capabilities. |
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| DC67323 |
1,9-Bis-Boc-1,5,9-triazanonane
Featured
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| DC67325 |
(S)-ACE-OH
Featured
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(S)-ACE-OH is a molecular glue exhibiting anticancer properties by facilitating the degradation of nucleoporins and disrupting nucleocytoplasmic transport. It achieves this by inducing an interaction between the E3 ubiquitin ligase TRIM21 and the nucleoporin NUP98. |
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