| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC67305 | BMS-1166-N-piperidine-COOH Featured | BMS-1166-N-piperidine-COOH, a derivative of the potent PD-1/PD-L1 interaction inhibitor BMS-1166, serves as a key component in the design of PROTAC PD-1/PD-L1 degrader-1 (HY-131183). By binding to an E3 ligase ligand via a linker, this moiety facilitates the targeted degradation of PD-1/PD-L1, offering a novel approach to modulate immune checkpoint pathways. BMS-1166 itself is a highly effective inhibitor of the PD-1/PD-L1 interaction, with an IC50 of 1.4 nM, and it counteracts the immune-suppressive effects of the PD-1/PD-L1 checkpoint on T cell activation. This innovative strategy combines the inhibitory potency of BMS-1166 with the degradation capability of PROTAC technology, providing a promising tool for advancing cancer immunotherapy and immune-related research. |
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| DC60798 | 6-[1-(Hexyloxy)ethoxy]hexanal(MK16 tail) Featured | 6-[1-(Hexyloxy)ethoxy]hexanal is the tail fragement for MK16.MK16 is a novel blood-brain barrier (BBB)-crossing lipid nanoparticle (BLNP) platform developed for efficient mRNA delivery to the central nervous system (CNS). |
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| DC67306 | 1-Propanethiol, 3-(dimethylamino)-, 4-methylbenzenesulfonate (1:1) Featured |
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| DC67307 | 1-Piperazineethanamine, N-(phenylmethyl)- Featured |
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| DC67308 | CbzNH-PEG1-Br Featured |
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| DC67309 | H2N(CH2)3N(tert-butoxycarbonyl)(CH2)4NH2 Featured |
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| DC67310 | 1,4-Piperazinediethylamine Featured |
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| DC67311 | 1-Propanaminium, 2,3-dihydroxy-N,N,N-trimethyl-, chloride (1:1), (2R)- Featured |
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| DC67312 | 1-Propanethiol, 3-(diMethylaMino)-, hydrochloride Featured |
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| DC67313 | 6-Oxohexyl 2-hexyldecanoate Featured |
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