Cat. No. | Product name | CAS No. |
DC7953 |
GNE-493
Featured
GNE-493 is a potent, selective, and orally available dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR respectively. |
1033735-94-2 |
DC10546 |
GNE-495
Featured
GNE-495 is a potent and Selective MAP4K4 Inhibitor with IC50 of 3.7 nM. |
1449277-10-4 |
DC26078 |
GNE-616
Featured
GNE-616 (GNE616) is a highly potent, metabolically stable, subtype selective inhibitor of Nav1.7 with Ki of 0.79 nM (hNav1.7). |
2244895-99-4 |
DC10096 |
GNE-617
Featured
GNE-617 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with IC50 value of 5nM. |
1362154-70-8 |
DC12495 |
GNE-6640
Featured
GNE-6640 is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM). |
2009273-67-8 |
DC11555 |
GNE-6776
Featured
GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM . |
2009273-71-4 |
DC11729 |
GNE-781
Featured
GNE-781 is a potent, selective, non-CNS penetrant, orally active CBP/p300 bromodomain inhibitor with IC50 of 0.94/1.2 nM in TR-FRET assays. |
1936422-33-1 |
DC7419 |
GNE-7915
Featured
GNE-7915 is a highly potent, selective, and brain-penetrable LRRK2 small molecule inhibitor with IC50 of 9 nM in cellular LRRK2 assay; > 100 fold selectivity against a panel of 187 kianses(Ki). |
1351761-44-8 |
DC26024 |
GNE-8324
Featured
GNE-8324 is a potent and selective NMDA receptor PAM. |
1698901-76-6 |
DC7629 |
GNE-9605
Featured
GNE-9605 is a highly potent and selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor |
1536200-31-3 |
DC1062 |
GNF-2
Featured
GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, inhibiting the proliferation of the Bcr-Abl-expressing cells with IC50 of 138 nM. |
778270-11-4 |
DC7420 |
GNF-5
Featured
GNF-5, an analogue of GNF-2 with improved pharmacokinetic properties, is a selective non-ATP competitive inhibitor of Bcr-Abl with an IC50 value of 0.22±0.1 uM (Wild type Abl). |
778277-15-9 |
DC7136 |
GNF-5837
Featured
GNF-5837 is a potent pan-Trk inhibitor which display antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). |
1033769-28-6 |
DC9285 |
GNF-7
Featured
GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of <5 nM, 61 nM, 122 nM, 136 nM, and 133 nM for M351T, T315I, E255 V, G250E, and c-Abl, respectively. |
839706-07-9 |
DC7660 |
Go 6983
Featured
Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ. |
133053-19-7 |
DC22100 |
GO289
Featured
GO289 (GO-289, GO 289) is a potent and selective inhibitor of casein kinase 2 (CK2) with IC50 of 7 nM in in vitro kinase assays, shows minor effects on CKIδ and CKIα activity in vitro. |
694522-87-7 |
DC20393 |
Golgicide A
Featured
Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1, inhibits the effect of shiga toxin on protein synthesis with IC50 of 3.3 uM. |
1139889-93-2 |
DC26017 |
Golotimod (SCV-07)
Featured
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. |
229305-39-9 |
DC23028 |
Gomisin A
Featured
Gomisin A has anti-inflammatory, antihypertensive, neuroprotective, and anti-proliferation properties, it induces marked protective effects against hepatic and renal injury induced by CCl(4) exposure through differential regulation of the MAPK signal tran |
58546-54-6 |
DC12542 |
GOT1 inhibitor 2c
Featured
GOT1 inhibitor 2c is a first-in-class, non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with IC50 of 8.2 uM.. |
732973-87-4 |
DC9375 |
GPDA
Featured
GPDA(Glycylproline p-nitroanilide tosylate) is the substarate of X-Prolyl dipeptidyl-aminopeptidase in the enzyme assay. |
65096-46-0 |
DC7137 |
Filgotinib(GLPG0634)
Featured
GPLG0634 is a novel inhibitor of JAK1 and JAK2 with IC50 of 10nM and 28nM respectively. |
1206161-97-8 |