| DC10015 |
MELK-8a
Featured
|
MELK-8a is a novel MELK inhibitor. |
|
| DC11465 |
MELK-T1
Featured
|
MELK-T1 is a potent and selective inhibitor of protein kinase MELK. |
|
| DC9050 |
Melphalan
Featured
|
Melphalan(Sarcolysin; L-PAM) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents; attaches the alkyl group to the guanine base of DNA. |
|
| DC9526 |
Meptazinol (hydrochloride)
Featured
|
Meptazinol Hcl(WY-22811 Hcl) is a unique centrally active opioid analgesic.
|
|
| DC7195 |
JAK Inhibitor I(Merck 5, Pyridone 6)
Featured
|
Merck 5 is a potent and reversible ATP-competitive inhibitor of the JAK kinases (JAK1, JAK2, JAK3, and Tyk2). It also blocks IL2 and IL4 dependent proliferation of CTLL cells and inhibits the phosphorylation of STAT5. |
|
| DC22506 |
Merck60
Featured
|
Merck60 (BRD 6929, Compound-60) is a potent, selective and brain-penetrant inhibitor of HDAC1 and HDAC2 with IC50 of 1 nM and 8 nM respectively. |
|
| DC11419 |
Merimepodib
Featured
|
Merimepodib(VX-497) is a novel noncompetitive inhibitor of IMPDH (Inosine monophosphate dehydrogenase). |
|
| DC20130 |
meso-Erythritol
Featured
|
meso-Erythritol is a sugar alcohol that occurs naturally in a variety of foods (e.g., pear, watermelon), is 60-80% as sweet as sucrose, and is an approved low-calorie sweetener food additive. |
|
| DC22157 |
Metarrestin
Featured
|
Metarrestin (ML246) is a specific inhibitor of perinuclear compartment (PNC), disrupts PNCs in PC3M-GFP-PTB cells with IC50 of 0.39 uM, specifically binds eEF1A2. |
|
| DC4182 |
Temozolomide
Featured
|
Methazolastone (Temozolomide, Temodar, Temodal) is a DNA damage inducer. |
|
| DC10575 |
Methyl 13-cis-4-Oxoretinoate
Featured
|
Methyl 13-cis-4-Oxoretinoate is a bioactive chemical. |
|
| DC20131 |
Methyl 3,4-dihydroxybenzoate
Featured
|
Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect. |
|
| DC8616 |
S-(5'-Adenosyl)-L-methionine chloride（SAM）
Featured
|
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). |
|
| DC9527 |
Methylnaltrexone (Bromide)
Featured
|
Methylnaltrexone Bromide is a pheriphally-acting μ-opioid antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation.
|
|
| DC8974 |
Mexiletine Hydrochloride
Featured
|
Mexiletine hydrochloride is a non-selective voltage-gated sodium channel blocker; Class IB anti-arrhythmic compound. |
|
| DC10917 |
MF-094
Featured
|
MF-094 (MF094) is a potent, highly selective inhibitor of ubiquitin specific protease 30 (USP30) with IC50 of 0.12 uM, demonstrates <30% inhibitory activity for a panel of 22 USPs assays at 10 uM. |
|
| DC7651 |
MF63
Featured
|
MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively. |
|
| DC22145 |
MF-766
Featured
|
MF-766 (MF766) is a highly potent and selective EP(4) antagonist with binding Ki of 0.23 nM, displays no significant affinity (>7000-fold selectivity) against other PG receptors (IC50>1500 nM); behaved as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay; exhibits blockade of inhibition of TNFa-induced IP10 release by the specific EP4 agonist L-000902688 (IC50=9.5 nM); demonstrates potency and efficacy of in the rat AIA model measuring inhibition of paw swelling. |
|
| DC7794 |
MG149
Featured
|
MG 149 is an inhibitor of histone acetyltransferases (HAT) with IC50 values of 74μM and 47μM for Tip60 and MOF, respectively. |
|
| DC7702 |
MG-101
Featured
|
MG-101 is a calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. |
|
| DC7816 |
MG-132
Featured
|
MG-132 is an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM. |
|
| DC7196 |
MGCD0103 (Mocetinostat)
Featured
|
MGCD0103 (Mocetinostat) is a potent HDAC inhibitor with IC50 of 0.15, 0.29 and 1.66 μM for HDAC 1, HDAC 2 and HDAC 3, respectively. |
|
| DC9995 |
MGL-3196(Resmetirom)
Featured
|
MGL-3196 is a potent and highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemia. |
|
| DC22146 |
MGV354
Featured
|
MGV354 is a novel potent, selective soluble Guanylate Cyclase (sGC) activator, lowers intraocular pressure (IOP) in preclinical models of glaucoma.. |
|
| DC8074 |
MHY1485
Featured
|
MHY1485 is mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes. |
|
| DC9503 |
MI 2 (MALT1 inhibitor)
Featured
|
MI 2(MALT1 inhibitor) is a small molecule and irreversible inhibitor of MALT1 with IC50 of 5.84 uM(suppression of proliferation in ABCDLBCL). |
|
| DC8546 |
MI-136
Featured
|
MI-136 inhibits DHT-induced expression of androgen receptor (AR) target genes. |
|
| DC7621 |
MI 2 (Menin-MLL Inhibitor)
Featured
|
MI-2 is an inhibitor of MALT1 with IC50 value of 5.84 μM. |
|
| DC20449 |
MI-2-2
Featured
|
MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM); inhibits the interaction of menin with MLL-AF9 in HEK293 cells in a dose-dependent manner with 4-fold potentcy improvement over MI-2; suppresses growth of MLL-AF9–transformed BMCs; causes MV4:11 cells growth inhibition of with GI50 of 3 uM. |
|
| DC8246 |
MI-3 (Menin-MLL Inhibitor)
Featured
|
MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM. |
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