| DC10926 |
LY900009
Featured
|
LY900009 (LY-900009) is an orally active small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein. |
|
| DC23020 |
Lycobetaine（Ungeremine）
Featured
|
Lycobetaine（Ungeremine） is a potential biofungicide against Penicillium roqueforti and Aspergillus niger. |
|
| DC10715 |
LYN-1604
Featured
|
LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 μM against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM). |
|
| DC24081 |
Lyn-IN-1 (Synonyms: Bafetinib analog)
Featured
|
Lyn-IN-1 is a potent and selective dual Bcr-Abl/Lyn inhibitor.. |
|
| DC10358 |
Lys01 trihydrochloride
Featured
|
Lys01 trihydrochloride (Lys05) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay. |
|
| DC10508 |
Lys05
Featured
|
Lys05 is a new lysosomal autophagy inhibitor which potently accumulates within and deacidifies the lysosome of both cells and tumors, resulting in sustained inhibition of autophagy and tumor growth. |
|
| DC11106 |
Vafidemstat (ORY-2001)
Featured
|
Vafidemstat (ORY-2001) is an oral, brain penetrant drug that inhibits LSD1 and MAOB by reducing cognitive impairment, including memory loss and neuroinflammation. It also has neuroprotective effects. |
|
| DC8478 |
M 344
Featured
|
M 344 enhances the sensitivity of human squamous carcinoma cells to radiation and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 μM). |
|
| DC10751 |
M2698
Featured
|
M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. |
|
| DC12034 |
MA-0204
Featured
|
MA-0204 is a potent, selective PPARδ modulator with good pharmacokinetic properties. |
|
| DC20269 |
mAChR-IN-1
Featured
|
mAChR-IN-1 is a potent muscarinic cholinergic receptor(mAChR) antagonist with IC50 of 17 nM.. |
|
| DC1012 |
Macitentan (Actelion-1,ACT-064992)
Featured
|
macitentan (Actelion-1, ACT-064992) is an orally active, non-peptide dual endothelin (ET)A/B receptor antagonist with IC50 of 0.5 nM/391 nM. |
|
| DC9741 |
Mad2 inhibitor-1 (M2I-1)
Featured
|
Mad2 Inhibitor-1 (M2I-1) is a small molecule protein-protein interaction inhibitor targeting the mitotic spindle assembly checkpoint. |
|
| DC9693 |
Madrasin
Featured
|
Madrasin inhibits pre-mRNA splicing in vitro and modify splicing of endogenous pre-mRNA. |
|
| DC8125 |
ETH 4030(Magnesium ionophore III)
Featured
|
Magnesium ionophore III is an onophore used in solvent polymeric membrane electrodes for the assay of Mg2+ activities in blood serum in vitro. |
|
| DC10560 |
MAK683
Featured
|
MAK683 is a novel PRC2/EED inhibitor. |
|
| DC22143 |
MALAT1-IN-1
Featured
|
MALAT1 inhibitor 5 (Malat1 inhibitor 5) is a selective small molecule targeting of Metastasis-associated lung adenocarcinoma transcript 1 (Malat1/MALAT1 mouse/human), a highly conserved long non-coding RNA; does not affect Neat1 lncRNA levels. |
|
| DC12536 |
Malic Enzyme inhibitor ME1
Featured
|
Malic Enzyme inhibitor ME1 (ME1) is a small molecule inhibitor of Malic Enzyme (ME1) with IC50 of 0.15 uM, suppresses growth of human CRC cells in vitro, with little effect on normal rat intestinal epithelial cells.. |
|
| DC20141 |
Maltitol
Featured
|
Maltitol is a sugar alcohol used as a sugar substitute. It has 75-90% of the sweetness of sucrose (table sugar) and nearly identical properties. Maltitol may also be used as a plasticizer in gelatin capsules, as an emollient, and as a humectant. |
|
| DC23814 |
MAP4K4-IN-17
Featured
|
MAP4K4-IN-17 is a potent and highly selective MAP4K4 inhibitor with IC50 of 14.9 nM, showes improved overall drug-like properties compared to PF-06260933. |
|
| DC4217 |
Maraviroc
Featured
|
Maraviroc (Selzentry, UK-427857, Celsentri) is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM, respectively. |
|
| DC8909 |
Maribavir
Featured
|
Maribavir(GW257406X; BW1263W94; 1263W94) inhibits HCMV replication is by inhibition of an HCMV encoded protein kinase enzyme called UL97 or pUL97. |
|
| DC22297 |
Marmesin
Featured
|
Marmesin is a coumarin originally isolated from the mature bark of A. marmelos. |
|
| DC7460 |
Masitinib
Featured
|
Masitinib is a broad coronavirus 3CL inhibitor that effectively blocks replication of SARS-CoV-2. Science 20 Jul 2021: eabg5827 DOI: 10.1126/science.abg5827 |
|
| DC11524 |
Mavacamten（MYK-461）
Featured
|
Mavacamten（MYK-461）is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain. |
|
| DC8378 |
Mavatrep(JNJ-39439335)
Featured
|
Mavatrep is an orally bioavailable TRPV1 antagonist (Ki=6.5 nM), exhibits minimal effect on the enzymatic activity (IC50 > 25 μM) of CYP isoforms 3A4, 1A2, and 2D6. |
|
| DC7681 |
Mavoglurant (AFQ 056)
Featured
|
Mavoglurant (AFQ056) is an experimental drug candidate for the treatment of fragile X syndrome.It exerts its effect as an antagonist of the metabotropic glutamate receptor 5 (mGLU5). |
|
| DC11285 |
MAZ51
Featured
|
MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 µM) without blocking VEGFC-mediated stimulation of VEGFR2. |
|
| DC11236 |
MB-07811 (VK-2809)
Featured
|
MB-07811 (VK-2809) is an orally bioavailable, liver-targeted prodrug of MB07344, which is a thyroid hormone receptor-beta agonist (TRβ) agonist, efficiently converted to MB07344 by liver microsomes in vivo. |
|
| DC10957 |
MB725
Featured
|
MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM). |
|
