| DC73496 |
NRD-21 |
NRD-21 is a potent, selective, reversible, negative allosteric modulator of PAR1 with IC50 of 0.37 uM in calcium mobilization assays. |
|
| DC73497 |
TFLLRN-NH2 |
TFLLRN-NH2 is a potent, PAR1-selective agonist peptide with EC50 of 1.9 uM. |
|
| DC73498 |
Ogremorphin |
Ogremorphin (OGM, OGM8345) is a highly specific, first-in-class small-molecule inhibitor of GPR68 with IC50 of 0.71 uM. |
|
| DC73499 |
Ogremorphin-1 |
Ogremorphin-1 (OGM1) is a highly specific, first-in-class small-molecule inhibitor of GPR68 with IC50 of 0.16 uM. |
|
| DC73500 |
DC591053 |
DC591053 (DC 591053) is a selective small molecule agonist of relaxin family peptide receptor 4 (RXFP4) with pEC50 of 7.24 and pKi of 6.95, shows no activity against RXFP3. |
|
| DC73501 |
AZ-66 |
AZ-66 is a highly potent S1R/S2R antagonist with Ki of 0.31/1.76 nM, respectively. |
|
| DC73502 |
CM-304 |
CM-304 is a potent, selective sigma-1 receptor (S1R) antagonist with Ki of 3.41 nM, 100-fold selective over S2R. |
|
| DC73503 |
GM310 |
GM310 is a small molecule inhibitor of glycolysis, proteotoxicity, inflammation, and impairments in animal models of Alzheime's, Huntington's, and stroke by activation of the Sigma-1 receptor. |
|
| DC73504 |
JR1-157
Featured
|
JR1-157 is a potent selective sigma 2 receptor (σ2R) ligand with Ki value of 47 nM, >10-fold selectivity over σ1R. |
|
| DC73505 |
MAM03055A |
MAM03055A is a novel bivalent sigma-2 receptor/TMEM97 ligand with cytotoxic activity, exhibits high affinity and strong preference for sigma-2 receptor with Ki of 55.9 nM. |
|
| DC73506 |
RC-752 |
RC-752 is a potent, seletive sigma-1 receptor (S1R) antagonist with Ki of 6.2 nM, 50-fold selective over S2R, shows antinociceptive activity. |
|
| DC73508 |
CRN02481 |
CRN02481 is a potent and selective SST5 receptor agonist with EC50 of 0.37 nM (human SST5), with excellent selectivity against SST1, SST2, SST3 and SST4 receptors. |
|
| DC73509 |
S6821
Featured
|
S6821 (S 6821) is a potent and selective antagonist of the bitter taste receptor TAS2R8, exhibiting an IC50 value of 21 nM.
It demonstrates high selectivity across a panel of 16 TAS2Rs, effectively reduces the bitterness of coffee, and shows an excellent safety profile. |
|
| DC73510 |
Org 274179-0
Featured
|
Org 274179-0 is a highly potent, allosteric antagonist of the thyroid-stimulating hormone receptor (TSH receptor), inhibits bTSH-, hTSH- and M22-mediated CRE-luciferase transactivation in the CHO cell line. |
|
| DC73511 |
SYD5115
(SYD-5115, SYD 5115) |
SYD5115 (SYD-5115) is a potent, selective and orally bioavailable thyrotropin receptor (TSH-R) antagonist with IC50 of 48 and 62 nM for rTSHR and hTSHR, respectively. |
|
| DC73512 |
OPC-61815 |
OPC-61815 is a water-soluble phosphate ester pro-drug of Tolvaptan (Cat# PC-45125), which is an orally active vasopressin V2 receptor antagonist. |
|
| DC73513 |
RGH-122 |
RGH-122 is a potent, selective, and orally bioavailable V1a receptor antagonist with Ki/IC50 of 0.3/0.9 nM (hV1a) respectively, >100-fold selectiive over V2 receptor. |
|
| DC74590 |
Protokylol hydrochloride |
Protokylol hydrochloride(Caytine hydrochloride, JB-251 hydrochloride) is a salt form of protokylol and is an agonist of β-adrenergic receptor. Protokylol hydrochloride is also used as a bronchodilator. |
|
| DC74598 |
Fasoracetam (NS 105) |
Fasoracetam (NS 105) is a metabotropic glutamate receptor activator with a potential to treat vascular dementia. |
|
| DC74600 |
Lotiglipron
Featured
|
Lotiglipron (PF-07081532) is an orally active GLP-1R agonist. It reduces glucose and body weight, and has the potential to be used in Type 2 diabetes mellitus (T2DM) research. |
|
| DC74621 |
Icalcaprant |
Icalcaprant is a kappa-opioid receptor antagonist. |
|
